Chitosan-gelatin-based microgel for sustained drug delivery

Journal of Biomaterials Science. Polymer Edition
K WangR D K Misra

Abstract

We describe here the proof-of-concept of synthesizing microgels via cross-linking of chitosan and gelatin with succinimide-end polyethylene glycol (PEG). The introduction of PEG provided thermo-responsiveness to microgels, and the size of microgels significantly changed with increasing temperature. Furthermore, the microgel was biocompatible as confirmed in vitro by MTT assay with NIH 3T3 fibroblast and degradable. Chitosan-based microgels exhibited strong affinity to hydrophobic drug and prolonged release of folic acid was observed at physiological temperature with varying pH. The proposed cost-effective injectable microgels have the potential to serve as the delivery vehicle of hydrophobic bioactive molecules.

References

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Yuliang DongYongyue Wang
Jul 24, 2018·Small·Garima Agrawal, Rahul Agrawal
Oct 9, 2018·Journal of Biomaterials Science. Polymer Edition·Longfei LiJianguo He
Oct 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hyerim KimKangwon Lee
Oct 19, 2017·Experimental and Therapeutic Medicine·Liangfeng TangXianmin Xiao
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ana Mora-BozaJulio San Román
Jul 20, 2021·Drug Development and Industrial Pharmacy·Aimen KhalidAsim Ur Rehman
Jun 8, 2018·ACS Applied Materials & Interfaces·Nagarajan PadmavathyKaushik Chatterjee
Oct 15, 2020·Carbohydrate Polymers·Michelly Cristina Galdioli PelláAdley Forti Rubira
May 18, 2020·Carbohydrate Polymers·Michelly Cristina Galdioli PelláAdley Forti Rubira

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Methods Mentioned

BETA
Fluorescence
NMR
chemical modification

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