Chitosan-genipin microspheres for the controlled release of drugs: clarithromycin, tramadol and heparin.

Marine Drugs
Ruth HarrisAngeles Heras

Abstract

The aim of this study was to first evaluate whether the chitosan hydrochloride-genipin crosslinking reaction is influenced by factors such as time, and polymer/genipin concentration, and second, to develop crosslinked drug loaded microspheres to improve the control over drug release. Once the crosslinking process was characterized as a function of the factors mentioned above, drug loaded hydrochloride chitosan microspheres with different degrees of crosslinking were obtained. Microspheres were characterized in terms of size, morphology, drug content, surface charge and capacity to control in vitro drug release. Clarithromycin, tramadol hydrochloride, and low molecular weight heparin (LMWH) were used as model drugs. The obtained particles were spherical, positively charged, with a diameter of 1-10 microm. X-Ray diffraction showed that there was an interaction of genipin and each drug with chitosan in the microspheres. In relation to the release profiles, a higher degree of crosslinking led to more control of drug release in the case of clarithromycin and tramadol. For these drugs, optimal release profiles were obtained for microspheres crosslinked with 1 mM genipin at 50 °C for 5 h and with 5 mM genipin at 50 °C for 5 h, respect...Continue Reading

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Citations

May 25, 2011·Biomedical Microdevices·Cinzia Anna VenturaSilvana Tommasini
Apr 29, 2011·Journal of the Royal Society, Interface·Shih-Wei HsiangYueh-Sheng Chen
May 13, 2014·Carbohydrate Polymers·Porntip Pan-InSupason Wanichwecharungruang
Jul 9, 2013·Journal of Industrial Microbiology & Biotechnology·Jesús Fernández-LucasMiguel Arroyo
Jan 21, 2016·Journal of Microencapsulation·André São PedroElaine Cabral Albuquerque
Oct 11, 2015·International Journal of Pharmaceutics·Suguna Selvakumaran, Ida Idayu Muhamad
Mar 12, 2016·Neuroscience·Natasha Belanger-WilloughbyMichiru Hirasawa
Sep 22, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ashley C ParkerWarren O Haggard
Jul 14, 2011·Biotechnology Journal·Pelagia GlampedakiMarijn M C G Warmoeskerken
Sep 15, 2012·International Journal of Biological Macromolecules·Alessandro F MartinsEdvani C Muniz
Feb 6, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Jinghua XuXiangrong Zhang
May 20, 2016·International Journal of Biological Macromolecules·Ashwini KumarAwanish Kumar
Aug 21, 2014·ACS Applied Materials & Interfaces·Avik KhanMonique Lacroix
Feb 2, 2016·Tissue Engineering and Regenerative Medicine·Andréa Arruda Martins ShimojoMaria Helena Andrade Santana
Aug 28, 2020·International Journal of Biological Macromolecules·Felicity A WhiteheadStefan Kasapis
Jul 9, 2017·International Journal of Biological Macromolecules·Michelangelo IannoneMassimo Fresta
Jun 23, 2020·International Journal of Biological Macromolecules·Thaysa Ksiaskiewcz KaramCelso Vataru Nakamura

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Methods Mentioned

BETA
X-Ray
scanning electron microscopy

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