Chitosan improves insulin sensitivity as determined by the euglycemic-hyperinsulinemic clamp technique in obese subjects

Nutrition Research
Sandra O Hernández-GonzálezJosé A Robles-Cervantes

Abstract

In accordance with obesity is associated with insulin resistance and dyslipidemia and chitosan decrease weight and lipids, but its effect on insulin sensitivity is unknown. Our hypothesis for the research was that chitosan improves insulin sensitivity estimated with the euglycemic-hyperinsulinemic clamp technique in obesity. We undertook this study with the objective to determine the effect of chitosan on insulin sensitivity using the euglycemic-hyperinsulinemic clamp technique in obese patients during a 3-month period. A randomized, double-blind clinical trial was carried out in 12 obese adults without diabetes mellitus. During a 3-month period, 6 patients received chitosan (750 mg, 3 times per day) 30 minutes before meals, and the other 6 subjects received placebo. Serum glucose, total cholesterol, high-density lipoprotein cholesterol, and triglycerides (TG) were measured. Insulin sensitivity was estimated with the euglycemic-hyperinsulinemic clamp technique before and after the intervention. Insulin sensitivity increased significantly with the administration of chitosan (2.4 +/- 1.4 vs 3.6 +/- 1.4 mg kg(-1) min(-1); P = .043). In addition, there was a decrease in weight (90.7 +/- 14.2 vs 84.7 +/- 13.7 kg; P = .027), body mas...Continue Reading

References

Aug 24, 2001·The Journal of Pharmacy and Pharmacology·A K Singla, M Chawla
Feb 21, 2002·Biological & Pharmaceutical Bulletin·Koji Hayashi, Mikio Ito
Mar 15, 2006·Marine Biotechnology·Keisuke Kurita
Dec 21, 2006·Hormones : International Journal of Endocrinology and Metabolism·Maria BougouliaGeorge Koliakos
Nov 17, 2007·BMJ : British Medical Journal·Diana RuckerDavid C W Lau
Nov 27, 2008·Annals of Nutrition & Metabolism·Omar Jacques-CamarenaRoberto Medina-Santillán
Feb 14, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T ForstA Pfützner

❮ Previous
Next ❯

Citations

Jul 13, 2014·Biological Trace Element Research·Mirosław KrośniakRyszard Gryboś
Aug 20, 2015·Marine Drugs·Randy Chi Fai CheungWai Yee Chan
Jan 19, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Arrigo F G Cicero, Alessandro Colletti
Sep 29, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kavita PoddarLawrence J Cheskin
Jan 14, 2016·The Cochrane Database of Systematic Reviews·Louise HartleyKaren Rees
Jun 23, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M ShimojiD A Depireux

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.