Chitosan-pectin hybrid nanoparticles prepared by coating and blending techniques

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
A RampinoA Cesàro

Abstract

The preparation of chitosan nanoparticles in combination with pectins, as additional mucoadhesive biopolymers, was investigated. Pectins from apple and from citrus fruit were considered; polygalacturonic acid was taken as a reference. Tripolyphosphate was used as an anionic cross-linker. Two different techniques were compared, namely the coating and the blending. Coated nanoparticles (NPs) in the ratio pectin:NPs from 2:1 to 5:1 evidenced that the size of NPs increased as the amount of pectin (both from apple and citrus fruit) was increased. In particular, for NPs coated with pectin from citrus fruit the size ranges from 200 to 260nm; while for NPs coated with pectin from apple the size ranges from 330 to 450nm. A minimum value of Z-potential around -35mV was obtained for the ratio pectin:NPs 4:1, while further addition of pectin did not decrease the Z-potential. Also blended NPs showed a dependence of the size on the ratio of the components: for a given ratio pectin:tripolyphosphate the size increases as the fraction of chitosan increases; for a low ratio chitosan:pectin a high amount of tripolyphosphate was needed to obtain a compact structure. The effect of the additional presence of loaded proteins in chitosan-pectin nanopa...Continue Reading

References

Dec 14, 2002·International Journal of Pharmaceutics·Yongmei Xu, Yumin Du
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J BergerR Gurny
Apr 10, 2004·International Journal of Pharmaceutics·V R SinhaS Dhawan
Jul 31, 2007·International Journal of Pharmaceutics·Ellen HagesaetherS Arne Sande
Apr 24, 2008·AAPS PharmSciTech·Rakesh K MishraAjit K Banthia
Jul 30, 2008·Drug Development and Industrial Pharmacy·Constance L L SawCeline V Liew
Oct 28, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F BigucciV Zecchi
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Laura SerraNicholas A Peppas
Nov 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gavin P AndrewsDavid S Jones
Jun 24, 2009·Biomacromolecules·Francisco M GoycooleaMaría J Alonso
Aug 20, 2010·Colloids and Surfaces. B, Biointerfaces·E Gonzalez-MiraE B Souto
Aug 26, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Al-QadiC Remuñán-López
Mar 13, 2012·The AAPS Journal·Neil Desai
May 9, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mohammad FazilJaved Ali
Jul 31, 2012·International Journal of Pharmaceutics·Ioannis A SogiasVitaliy V Khutoryanskiy
Aug 23, 2012·International Journal of Pharmaceutics·Katayoun Derakhshandeh, Sahar Fathi
Dec 12, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Aurélie SchoubbenMaurizio Ricci
Apr 24, 2013·International Journal of Biological Macromolecules·Sudheesh K ShuklaBhekie B Mamba
Jun 19, 2013·Carbohydrate Polymers·Sarekha Woranuch, Rangrong Yoksan
Jul 9, 2013·International Journal of Pharmaceutics·Paolo BlasiMaurizio Ricci
Sep 3, 2013·International Journal of Pharmaceutics·Archana Pataskar BagreNarendra K Jain
Sep 4, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mamdouh Abdel MouezAhmed S Geneidi
Dec 30, 2014·International Journal of Pharmaceutics·T Marras-MarquezM D Veiga-Ochoa

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Citations

Oct 18, 2016·Journal of Biomedical Materials Research. Part a·Mariya V KonovalovaValery P Varlamov
Mar 17, 2017·International Journal of Biological Macromolecules·Aqdas NoreenKhalid Mahmood Zia
Dec 12, 2018·Future Medicinal Chemistry·Susanna SampaolesiLaura Russo
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Jalil RashediBehzad Baradaran
Feb 26, 2018·Polymers·Javier Pérez QuiñonesCarlos Peniche
Apr 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia Lara-EspinozaAgustín Rascón-Chu
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milica PantićZoran Novak
May 11, 2021·Carbohydrate Polymers·Thalia S A LemosAndré R Fajardo

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