Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks

International Journal of Biological Macromolecules
Rania A HashadAhmed S Geneidi

Abstract

At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable particle flocculation. Prepared formulations were characterized in terms of particle size (PS), zeta potential (ZP) and percentage yield (% yield). Artificial neural networks (ANN) were built up and used to identify the parameters that control nanoparticle (NP) size and yield, in addition to being tested for their ability to predict these two experimental outputs. Using these networks, it was found that TPP concentration has the greatest effect on PS and% yield. The most optimum formulation was characterized by a notable process yield reaching 91.5%, a mean hydrodynamic PS 227 nm, ZP+24.13 mv and spherical compact morphology. Successful Cs-TPP interaction in NP formation was confirmed by both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). This study demonstrated the ability of ANN to predict not only PS of the formed particles but also NP% yield. This may have a great impact on Cs-TPP NPs preparation and can be used to customize the required target formulations.

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Citations

Jun 11, 2016·International Journal of Biological Macromolecules·Rania A HashadSamar Mansour
Jul 20, 2016·International Journal of Biological Macromolecules·Pasquale SaccoIvan Donati
Feb 2, 2017·Beilstein Journal of Nanotechnology·Huijuan ZhangLee Jia
Jan 23, 2018·Polymers·Shaked EliyahuHavazelet Bianco-Peled
Apr 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrizia Bocchetta
Jul 28, 2020·AAPS PharmSciTech·Safa A Damiati
Nov 1, 2020·International Journal of Biological Macromolecules·Cynthia Lizeth Barrera-MartínezRené Darío Peralta-Rodríguez
Feb 5, 2021·International Journal of Pharmaceutics·Ming GaoCushla M McGoverin
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rodolpho Fagundes CorreaMaria Filomena Barreiro
Apr 30, 2021·International Journal of Nanomedicine·Marianne Joseph NaguibMahmoud Hassan Teaima
Apr 18, 2021·International Journal of Biological Macromolecules·Yale Luck NunesJosé C S Dos Santos
Oct 4, 2018·International Journal of Biological Macromolecules·Ezzeddin M A HejjajiGordon A Morris
Jun 16, 2021·Carbohydrate Polymers·Salma A FereigMona M A Abdel-Mottaleb
Jul 13, 2021·International Journal of Pharmaceutics·A AbruzzoF Bigucci
Nov 2, 2021·Drug Development and Industrial Pharmacy·Gilberto García-SalazarDavid Quintanar-Guerrero
Nov 5, 2020·Carbohydrate Polymers·Eduardo M CostaManuela E Pintado

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