Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Xiaobing HanXi Yang

Abstract

Our previous study has shown that the adoptive transfer of dendritic cells (DCs) freshly isolated from Chlamydia-infected mice (iIDCs), unlike those from control naive mice (iNDCs), can inhibit systemic and cutaneous eosinophilia induced by OVA exposure. In the present study, we examined the mechanism by which iIDC inhibits allergen-specific Th2 cell differentiation in vitro and in vivo. The study revealed that iIDCs exhibited higher surface expression of CD8alpha and the ICOS ligand (ICOS-L), as well as higher IL-10 and IL-12 production than iNDCs. In vitro DC:CD4(+) T cell coculture experiments showed that iIDCs could inhibit allergen-specific Th2 cell differentiation and that the inhibitory effect could be abolished by the blockage of IL-10 or IL-12 activity. More interestingly, the coblockade of IL-10 and the ICOS-L showed synergistic effect in enhancing allergen-driven Th2 cytokine production. Furthermore, adoptive transfer of iIDCs, but not iNDCs, to OVA sensitized mice significantly inhibited airway eosinophilia and mucus overproduction following intranasal challenge with OVA. Overall, the data demonstrate a critical role played by ICOS-L-expressing and IL-10-producing DCs from Chlamydia-infected mice in the infection-me...Continue Reading

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Citations

Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaobing HanXi Yang
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kamran KadkhodaXi Yang
Oct 9, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong BaiXi Yang
Mar 16, 2011·International Immunology·Kamran KadkhodaXi Yang
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperEleanor M Riley
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura BilenkiXi Yang
Jan 31, 2009·European Journal of Immunology·Lei JiaoXi Yang
Jan 5, 2011·Cellular & Molecular Immunology·Xi Yang, Xiaoling Gao
Jan 9, 2014·Inflammation·Hamid HakimiMohammad Kazemi Arababadi
Sep 29, 2020·Frontiers in Immunology·Dan-Yang Li, Xian-Zhi Xiong
Feb 15, 2013·Immunological Reviews·Xindong LiuChen Dong
Feb 13, 2020·Allergologia et immunopathologia·Natalia NedelkopoulouEvangelia Farmaki
Jan 29, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rony ThomasXi Yang
Jun 8, 2021·Frontiers in Immunology·Wenjing XiangZhou Zhou
Nov 29, 2011·Immunity·Carola G Vinuesa, Jason G Cyster

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