Chlamydia pecorum-Induced Arthritis in Experimentally and Naturally Infected Sheep.

Veterinary Pathology
Nina OstfeldNicole Borel

Abstract

Chlamydia pecorum is an obligate intracellular pathogen with a wide host range including livestock such as sheep, cattle, goats, and pigs as well as wildlife species such as koalas. Chlamydial polyarthritis is an economically important disease resulting in swollen joints, lameness, stiffness, and weight loss in young sheep. In the present study, tissues from sheep experimentally or naturally infected with Chlamydia pecorum were assessed by histopathology and immunohistochemistry. Carpal, hock, and stifle joints as well as spleen, liver, kidney, lymph nodes, lung, and brain of 35 sheep from different inoculation groups were available. Two different C. pecorum strains (IPA and E58), different routes of administration (intraarticular or intravenous), UVA-irradiated IPA strain, and corresponding noninfected control groups were investigated. Similar investigations on tissues from 5 naturally infected sheep were performed. The most obvious inflammatory lesions were observed in synovial tissues and, notably, in the renal pelvis from the experimentally infected group and naturally infected animals. This resulted in chronic or chronic-active arthritis and pyelitis. Intralesional chlamydial inclusions could be demonstrated by immunohisto...Continue Reading

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Nov 18, 2018·Pathogens and Disease·Nicole BorelRenata Flury

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Citations

Jun 13, 2021·Veterinary Research·Tom CluneCaroline Jacobson

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Methods Mentioned

BETA
PCR
transmission electron microscopy

Software Mentioned

geepack
lme4
Desctools
R
multcomp
glmmTMB

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