PMID: 11310268Apr 20, 2001Paper

Chlamydia pneumoniae and cerebrovascular disease

Revista de neurologia
J Linares-PalominoM C Maroto

Abstract

Chlamydia pneumoniae has relationship with artherosclerosis of carotid artery by seroepidemiological studies and by demonstration of the bacteria in atheromata. We made a case-control study to know the seroprevalence of chronic infection of C. pneumoniae and the presence of the bacteria in arterial biopsies. The cases group was constituted by 26 patients undergoing carotid surgery. In the control group there were 50 patients without atherosclerosis and who underwent removal of their varicose veins. There were matched for sex, age and smoking. We obtained serum samples to determinate IgG antibodies against MOMP by MIF and ELISA. In the cases group, we got the arterial biopsies from carotid artery, and from pudendal arteries in control group. We determined chlamydial DNA on the biopsies by heminested PCR (primers: HL-1, HM-1, HR-1). We measured fibrinogen in both groups. By MIF technique, the seroprevalence was (IgG > 1:32) 69.23% cases versus 24% controls (OR: 7.12, CI: 2.47-20.48). The ELISA showed 76.92% of seropositivity in cases versus 16% in controls (OR: 17.5, CI: 95%: 5.35-57.23). The DNA of C. pneumoniae was found in 18 cases and 6 controls, (p < 0.0001, chi 2). We did not find any relationship between fibrinogen levels ...Continue Reading

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
P PieniazekS J Konturek
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Babak S JahromiBrian Chiu
Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
Ramin Behroozian, Elvis Moradkhan
© 2021 Meta ULC. All rights reserved