Chlamydia pneumoniae infection and ischemic heart disease in hemodialysis patients

Transplantation Proceedings
M WszolaW Rowinski

Abstract

Ischemic heart disease and other atherosclerotic complications are the prominent causes of death among hemodialyzed end-stage renal disease (ESRD) patients and renal transplant recipients. Numerous articles in recent years have raised the possibility of an infective factor, especially Chlamydia pneumoniae, in the development of atherosclerosis and its complications. The aim of this study was to assess the incidence of chronic C pneumoniae infection and its association with ischemic heart disease and atherosclerosis in a population of patients with ESRD awaiting renal transplantation. The studied group consisted of 164 subjects: 99 ESRD patients (heart disease [HD] group) who were hospitalized for vascular access creation (27), pretransplantation nephrectomy (47), or kidney transplantation (25), and a control group of 65 subjects consisting of 50 healthy blood donors and 15 multiorgan donors. C pneumoniae was detected in vascular wall fragments, kidney biopsy specimens and peripheral blood monocytes using real time polymerase chain reaction (PCR). Serum immunoglobulin IgG and IgA anti-C pneumoniae antibodies were detected using Enzyme-linked immunosorbent assay (ELISA) and a lipid profile (cholesterol, high-density lipoprotein [...Continue Reading

References

Apr 1, 1994·Microbial Pathogenesis·S S Kaukoranta-TolvanenM Leinonen
Sep 17, 1998·The New England Journal of Medicine·R G Luke
Feb 22, 2000·Mineral and Electrolyte Metabolism·T B Drüeke
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F LocatelliC Zoccali

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Citations

Oct 21, 2006·Current Opinion in Nephrology and Hypertension·Jennifer M MacRae
Nov 6, 2012·Journal of Zhejiang University. Science. B·Paweł OlczykKrystyna Olczyk

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