Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR-/- Mouse Strain

BioMed Research International
Ildikó LantosKatalin Burián

Abstract

Hyperlipidaemia model animals have been used to elucidate the role of Chlamydia pneumoniae (Cpn) infection in atherosclerosis. The aims of this study were to investigate the proatherogenic effect of multiple Cpn infections in ApoB100only/LDLR-/- mice which based on lipid profile can be regarded as the most suitable mouse model of human hypercholesterolemia and to compare the lesion development to that in a major atherosclerosis model ApoE-/- mice. Aorta samples of ApoB100only/LDLR-/- mice infected three times with Cpn were subjected to morphometric analyses. Morphometric evaluation disclosed that Cpn infections exacerbated atherosclerosis development in the aortic root and descending aorta of the mice fed with normal diet. Viable Cpn was detected in the ascending aorta by RT-PCR. Chlamydial 16SrRNA expression showed the presence of viable Cpn in the aorta of infected animals. A similar rate of acceleration of atherosclerosis was observed when the infection protocol was applied in ApoB100only/LDLR-/- and in ApoE-/- mice. Similar to ApoE-/- mice, ApoB100only/LDLR-/- mice with more human-relevant serum lipoprotein composition develop increased atherosclerosis after Cpn infections; thus this mouse strain can be used as a model of i...Continue Reading

References

Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
Mar 1, 1995·The Journal of Infectious Diseases·Z P YangJ T Grayston
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R V FareseS G Young
Apr 1, 1997·The Journal of Infectious Diseases·T C MoazedL A Campbell
Aug 13, 1998·Nature Medicine·D J Rader, G A FitzGerald
Sep 23, 2000·Nature·A J Lusis
Dec 20, 2000·The Journal of Infectious Diseases·N M RothsteinC J Lowenstein
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Robert H Knopp, Pathmaja Paramsothy
Mar 14, 2008·Clinical Science·Caroline Watson, Nicholas J Alp
Jun 3, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Z KisV Endresz
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshikazu NaikiMoshe Arditi
Jan 28, 2009·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 18, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F BlasiS Aliberti
Nov 28, 2009·Journal of the American College of Cardiology·Peter LibbyUNKNOWN Leducq Transatlantic Network on Atherothrombosis
Jan 30, 2010·Journal of Immunological Methods·S DhanasekaranUNKNOWN TB Trials Study Group
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuang ChenMoshe Arditi
Dec 17, 2010·World Journal of Cardiology·Giovanni FazioSalvatore Novo
Mar 23, 2011·Microbial Pathogenesis·Anita M TuomainenPirkko J Pussinen
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Feb 7, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tímea MosolygóKatalin Burián
Apr 9, 2014·Frontiers in Cellular and Infection Microbiology·Lee Ann Campbell, Michael E Rosenfeld
May 29, 2014·World Journal of Clinical Cases·Fatemeh Ramezani KapourchaliMohammed H Moghadasian
Jun 7, 2014·Circulation Research·Jacob Fog BentzonErling Falk
May 26, 2015·Archives of Medical Research·Lee Ann Campbell, Michael E Rosenfeld
Jan 20, 2016·Antioxidants·Tomoko Kurita-OchiaiMasafumi Yamamoto

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
IgA
ELISA
Infection

Software Mentioned

BLAST
ScopePhoto
SigmaPlot
JMicroVision

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.