Chlamydia pneumoniae-specific serum immune complexes in patients with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
John ParrattRobert Swingler

Abstract

The significance of Chlamydia pneumoniae infection in patients with multiple sclerosis (MS) is unclear. We determined the frequency of serum C. pneumoniae-specific immune complexes in patients with MS, neurological (OND) and healthy controls in a blinded, cross-sectional study. C. pneumoniae immune complexes were detected in 24% (38/156) of MS patients, 16% (11/69) of OND and 15% (77/499) of healthy controls. The odds ratio for all MS patients was 3.95 (95% CI: 2.15 to 7.24; P < 0.0001) accounting for the covariates: sex, age, socio-economic status and area of residence. The odds ratio for recently diagnosed MS patients was 4.33 (95% CI: 1.76 to 10.64; P = 0.001). Systemic C. pneumoniae infection is more frequent in MS patients than the healthy population and occurs early in the course of the disease.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1995·Clinical Immunology and Immunopathology·J F TsaiJ H Tsai
Aug 11, 1994·The New England Journal of Medicine·M SocanD Kese
Oct 1, 1995·Clinical Microbiology Reviews·C C KuoJ T Grayston
Oct 1, 1996·Journal of Clinical Microbiology·N TsumuraM R Hammerschlag
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·A EssigR Marre
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·M S ElkindR L Sacco
Nov 4, 2000·Journal of Clinical Microbiology·M R HammerschlagB Kalman
Apr 5, 2001·Trends in Microbiology·J C Tsai, D H Gilden
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S F DowellUNKNOWN C. pneumoniae Workshop Participants
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C LenzR H Swanborg
Aug 24, 2001·Journal of Neurology·A SaizM T Jimenez de Anta
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Beata TarnackaAnna Członkowska
Aug 9, 2002·Multiple Sclerosis : Clinical and Laboratory Research·M KaufmanH J Norton
Oct 3, 2002·Multiple Sclerosis : Clinical and Laboratory Research·Q HaoT Saida
Dec 18, 2002·The Journal of Experimental Medicine·Caigan DuSubramaniam Sriram
Jan 16, 2003·Trends in Microbiology·Richard S Stephens
Feb 28, 2003·Epidemiology·Kassandra L MungerAlberto Ascherio
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Constanze BreithauptUwe Jacob
Oct 8, 2003·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Stylianos ChatzipanagiotouChryssoula Nicolaou
Mar 25, 2004·Infection and Immunity·Richard J HoganPeter Timms
Mar 11, 2005·European Journal of Epidemiology·Søren P JohnsenHenrik T Sørensen
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Eva BrandénGöran Tornling
Sep 2, 2005·The Journal of Infectious Diseases·Subramaniam SriramWilliam O Whetsell
Sep 2, 2005·The Journal of Infectious Diseases·Margaret R HammerschlagCharlotte Gaydos
Jan 21, 2006·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindMarco R Di Tullio
Jun 15, 2006·Journal of Medical Microbiology·Hideaki IkejimaYoshimasa Yamamoto
Jul 28, 2006·Neurology·Jorge CorrealeWendy Gilmore
Sep 26, 2006·Trends in Microbiology·Charles W Stratton, David B Wheldon

❮ Previous
Next ❯

Citations

Oct 31, 2012·International Journal of Molecular Sciences·Cullen O'GormanBruce Taylor
Jul 3, 2010·International Journal of Medical Sciences·Ivan M PetyaevYuriy K Bashmakov
May 17, 2011·Neurologia i neurochirurgia polska·Maryam AghaeiMohammad R Falahian
Oct 16, 2015·Bulletin of Experimental Biology and Medicine·M V IvanovaM N Zakharova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.