PMID: 11929685Apr 4, 2002Paper

Chlamydia pneumoniae, systemic inflammation and the risk of venous thrombosis

Diagnostic Microbiology and Infectious Disease
B MarahaM den Heijer

Abstract

Inflammatory mediators are involved in activation of the coagulation system, and elevated plasma concentrations of IL-6 and IL-8 are associated with an increased risk of venous thrombosis. Using serologic and molecular biologic tests, we investigated in a case-control study on patients with recurrent venous thrombosis the association between Chlamydia (C) pneumoniae and venous thrombosis and we evaluated the relation between C. pneumoniae serology and the cytokines IL-6 and IL-8. The presence of C. pneumoniae antibody titers > or = 1:16 was not associated with an increased risk of venous thrombosis (odds ratio 0.8 95% CI, 0.4-1.7). Circulating C. pneumoniae-DNA was detected in only one patient and two control subjects. IgG antibody titers against C. pneumoniae were not correlated with the concentrations of IL-6 and IL-8. These results indicate that the inflammatory process shown in patients with venous thrombosis is not related to C. pneumoniae.

References

Nov 14, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H M FreidankK Eckert
Apr 21, 1999·Lancet·F R Rosendaal
Jun 18, 1999·Southern Medical Journal·H A Hassan, J P Raufman
Jun 6, 2000·The Journal of Infectious Diseases·R W PeelingJ Schachter
Apr 18, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B MarahaM Peeters

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Citations

Oct 29, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D L Hahn
Oct 30, 1998·Molecular Medicine Today·C Kuo, L A Campbell
Jan 24, 2016·Annals of Vascular Surgery·Sang-Dong KimJang-Sang Park
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·P Prandoni
Aug 19, 2007·Journal of Internal Medicine·P Prandoni

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