Chlamydia-secreted protease CPAF degrades host antimicrobial peptides

Microbes and Infection
Lingli TangGuangming Zhong

Abstract

Chlamydia trachomatis infection in the lower genital tract, if untreated, can ascend to the upper genital tract, potentially leading to complications such as tubal factor infertility. The ascension involves cell-to-cell spreading, which may require C. trachomatis organisms to overcome mucosal extracellular effectors such as antimicrobial peptides. We found that among the 8 antimicrobial peptides tested, the cathelicidin LL-37 that is produced by both urogenital epithelial cells and the recruited neutrophils possessed a most potent antichlamydial activity. Interestingly, this antichlamydial activity was completely inhibited by CPAF, a C. trachomatis-secreted serine protease. The inhibition was dependent on CPAF's proteolytic activity. CPAF selectively degraded LL-37 and other antimicrobial peptides with an antichlamydial activity. CPAF is known to secrete into and accumulate in the infected host cell cytoplasm at the late stage of chlamydial intracellular growth and may be released to confront the extracellular antimicrobial peptides before the intra-inclusion organisms are exposed to extracellular environments during host cell lysis and chlamydial spreading. Thus, the finding that CPAF selectively targets host antimicrobial pep...Continue Reading

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Citations

Mar 24, 2016·Microbes and Infection·Karen F Ross, Mark C Herzberg
Mar 16, 2016·Pharmaceuticals·Nongnuj TanphaichitrDuane Hickling
Oct 21, 2016·Microbes and Infection·Zhangsheng YangGuangming Zhong
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Jul 7, 2016·Infection and Immunity·Zhangsheng YangGuangming Zhong
May 11, 2016·Infection and Immunity·Pavel BobrovskyVassili Lazarev
Jan 11, 2019·American Journal of Reproductive Immunology : AJRI·Eleanne F van EssSander Ouburg
Aug 27, 2019·Frontiers in Cellular and Infection Microbiology·Tobias C KunzThomas Rudel
Jun 28, 2018·Nature Microbiology·Karthika RajeeveThomas Rudel
Jun 15, 2018·Frontiers in Cellular and Infection Microbiology·Bhupesh K PrustyThomas Rudel
Jun 8, 2018·Mucosal Immunology·Fiona D BarrMarta Rodriguez-Garcia

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