Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages

Nature Communications
Patiyan AnderssonPhilip M Giffard

Abstract

Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH.

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Citations

Mar 23, 2019·Nanomedicine·Aseel Mahmood Ibrahim Al-MashahedahJagat Rakesh Kanwar
Mar 12, 2020·Microorganisms·Charlotte A JonesColette E O'Neill
Apr 17, 2016·Sexually Transmitted Infections·Philip M GiffardSuzanne M Garland
Feb 22, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J A DanielewskiS N Tabrizi
Jun 11, 2017·Sexually Transmitted Infections·Philip M GiffardPatiyan Andersson
Jan 9, 2019·Frontiers in Cellular and Infection Microbiology·Colette Elizabeth O'NeillIan Nicholas Clarke
May 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shardulendra P Sherchand, Ashok Aiyar
Nov 7, 2019·Parasites & Vectors·Abdulazeem Abdulsalam Ibrahim AlkhidirHarry Pickering
Oct 10, 2020·The Journal of Infectious Diseases·Harry PickeringScott D Nash

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Datasets Mentioned

BETA
NC012686

Methods Mentioned

BETA
electrophoresis

Software Mentioned

Integrative Genome Viewer ( IGV )
samtools
bcftools
SMALT
SPANDx
PLINK
fastq
RAxML

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