Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice.

Infection and Immunity
H SuRichard P Morrison

Abstract

The importance of antibody-mediated immunity in primary and secondary Chlamydia trachomatis genital tract infections was examined by using a definitive model of B-cell deficiency, the microMT/microMT gene knockout mouse. Vaginally infected B-cell-deficient microMT/microMT mice developed a self-limiting primary infection that was indistinguishable from infection of control C57BL/6 mice. Sera and vaginal secretions from infected mice were analyzed for anti-Chlamydia antibodies. C57BL/6 mice produced high-titered serum anti-Chlamydia immunoglobulin G2a (IgG2a), IgG2b, and IgA antibodies, and vaginal washes contained predominately anti-Chlamydia IgA. Serum and vaginal washes from infected B-cell-deficient mice were negative for anti-Chlamydia antibody. T-cell proliferation and delayed-type hypersensitivity assays were used as measures of Chlamydia-specific cell-mediated immunity and were found to be comparable for C57BL/6 and B-cell-deficient mice. Seventy days following primary infection, mice were rechallenged to assess acquired immunity. B-cell-deficient mice which lack anti-Chlamydia antibodies were more susceptible to reinfection than immunocompetent C57BL/6 mice. However, acquired immune resistance was evident in both strains...Continue Reading

References

Oct 1, 1992·Infection and Immunity·R G RankD M Williams
Mar 1, 1991·Infection and Immunity·K H Ramsey, R G Rank
Jun 1, 1985·Infection and Immunity·R G RankA L Barron
May 1, 1967·American Journal of Ophthalmology·S P WangE R Alexander
May 1, 1967·American Journal of Ophthalmology·R L WoolridgeK H Cheng
Aug 1, 1993·The Journal of Infectious Diseases·G I ByrneS Everson
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W L BeattyR P Morrison
Mar 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·J T GRAYSTONI H CHANG

❮ Previous
Next ❯

Citations

Mar 2, 2002·Immunology·Terri MooreJoseph U Igietseme
Jun 25, 2003·Current Opinion in Infectious Diseases·Martina Johansson, Nils Y Lycke
Sep 23, 2008·American Journal of Reproductive Immunology : AJRI·Kelly A CunninghamKenneth W Beagley
Jan 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raymond M JohnsonJames E Slaven
Mar 5, 2013·PLoS Neglected Tropical Diseases·Victor H HuMatthew J Burton
Feb 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catarina V NogueiraMichael N Starnbach
Sep 8, 2016·Infection and Immunity·Elizabeth K NaglakRichard P Morrison
Feb 22, 2017·Frontiers in Cellular and Infection Microbiology·Jennifer H ShawErika I Lutter
Mar 23, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph U IgietsemeHarlan D Caldwell
Feb 17, 2001·Infection and Immunity·J U IgietsemeL L Perry
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hao ShenRafi Ahmed
Oct 27, 2004·Infection and Immunity·Heather K MaxionKathleen A Kelly
Oct 13, 2006·Current Opinion in Infectious Diseases·X Yang, R C Brunham
May 16, 2002·Infection and Immunity·Richard P Morrison, Harlan D Caldwell
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis O EkoJoseph U Igietseme
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra G Morrison, Richard P Morrison
Sep 11, 2004·Journal of Medical Microbiology·Farida Hamdad-DaoudiFrançois Eb
Feb 11, 2009·Immunology and Cell Biology·Alison J CareyKenneth W Beagley
May 16, 2014·Immunology·Charles W ArmitageKenneth W Beagley
Oct 13, 2001·Infection and Immunity·M S PateJ Mestecky
Jun 17, 2003·Journal of Medical Microbiology·David Longbottom
Mar 29, 2000·Scandinavian Journal of Immunology·C SvanholmM E Rottenberg
Jul 14, 2010·American Journal of Reproductive Immunology : AJRI·Kelly A CunninghamKenneth W Beagley
Nov 6, 2007·Cellular Microbiology·Nadia R Roan, Michael N Starnbach
Oct 7, 2009·Expert Review of Vaccines·Daniel D RockeyGuangming Zhong
Mar 14, 2009·European Journal of Immunology·Paul J Maglione, John Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.