Chlamydia trachomatis infant pneumonitis: comparison with matched controls and other infant pneumonitis

The New England Journal of Medicine
H R HarrisonE R Alexander

Abstract

We determined the prevalence of Chlamydia trachomatis infection in 30 consecutive hospitalized infants less than six months of age with pneumonitis and in 28 matched controls (nine of 30 vs. one of 28. P less than 0.05). In comparing 16 cases of pneumonitis due to C. trachomatis with 27 not due to that agent, we found several distinguishing clinical and laboratory features: C. trachomatis was highly correlated with radiographic hyperinflation, prolonged cough and congestion, greater than or equal to 400 eosinophils per cubic millimeter and serum lgG greater than or equal to 500 and lgM greater than or equal to 110 mg per deciliter. C. trachomatis was responsible for 13 of 21 cases seen at three to 11 weeks vs. three of 22 seen at other ages. Antibody to C. trachomatis in tears (13 of 14 vs. two of 27), nasopharynx (12 of 14 vs. one of 27) and blood (16 of 16 vs. two of 23) was specific for C. trachomatis pneumonitis. C. trachomatis is prevalent among hospitalized infants with pneumonitis. Conjunctival infection precedes C. trachomatis pneumonitis more commonly than has previously been thought.

References

Jun 5, 1975·The New England Journal of Medicine·K K HolmesE R Alexander
May 19, 1977·The New England Journal of Medicine·G T FrommellJ D Schwartzman
May 2, 1950·Lancet·B R JONESC H SMITH

Citations

Jun 1, 1988·European Journal of Epidemiology·A Stary, J Söltz-Szöts
Mar 1, 1982·European Journal of Pediatrics·U B Schaad, E Rossi
Jan 1, 1982·Infection·J D Oriel
Feb 1, 1981·The American Journal of Medicine·D W Fraser
May 5, 2001·Diagnostic Microbiology and Infectious Disease·Z SamraM Dan
Nov 1, 1987·The Journal of Laryngology and Otology·S E Kent, R S Matthews
May 11, 1978·The New England Journal of Medicine·M R Hammerschlag
Jul 8, 1982·The New England Journal of Medicine·J I ItoR E Sobonya
Dec 13, 1984·The New England Journal of Medicine·D I BernsteinM A Lovett
Jan 30, 1986·The New England Journal of Medicine·J SchachterE Bishop
May 22, 1986·The New England Journal of Medicine·L Mascola, M E Guinan
Feb 8, 2002·The New England Journal of Medicine·Kenneth McIntosh
Jun 27, 2000·Journal of Women's Health & Gender-based Medicine·Cathleen WalshKathleen L Irwin
Aug 26, 1999·The Pediatric Infectious Disease Journal·P TorzilloI Riley
Oct 26, 1999·The Pediatric Infectious Disease Journal·D LehmannM P Alpers
Feb 1, 1986·Australian Paediatric Journal·G L Gilbert
May 1, 1985·Antimicrobial Agents and Chemotherapy·J P KellyW J Alexander
Mar 1, 1981·Archives of Disease in Childhood·E ReesN Lee
Feb 1, 1984·Archives of Disease in Childhood·P T Rudd, D Carrington
Mar 1, 1980·Journal of Clinical Pathology·D Taylor-Robinson, B J Thomas
Jan 1, 1986·Postgraduate Medical Journal·D CunninghamM Soukop
Oct 1, 1980·The British Journal of Venereal Diseases·E M DunlopS S Al-Egaily
Oct 1, 1982·The British Journal of Venereal Diseases·B T GohK S Lim
Feb 1, 1992·Genitourinary Medicine·S Estreich, G E Forster
May 4, 2010·Pediatrics in Review·Amanda Richards, Judith A Guzman-Cottrill
Jul 1, 1994·Pediatric Annals·M R Hammerschlag
Oct 8, 2005·Seminars in Pediatric Infectious Diseases·Toni Darville
Apr 1, 1996·Dermatologic Clinics·G T Terezhalmy, G D Naylor
Jan 1, 1990·Pediatric Pathology·M GriffinW Andrews
Sep 1, 1979·Acta paediatrica Scandinavica·A HallbergT Ripa
Dec 1, 1986·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C D MeriwetherR J Sokol
Sep 1, 1983·Clinical Pediatrics·R E RingelM A Berman
Aug 1, 1982·Clinical Pediatrics·G MundelD Sompolinsky
Feb 1, 1980·Clinical Pediatrics·V H San JoaquinJ M Hautala
Jun 1, 1988·Clinics in Perinatology·P J Rettig
Jul 20, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Madhulika JupelliBernard P Arulanandam
Feb 2, 2018·The Pediatric Infectious Disease Journal·Minna HonkilaTerhi Tapiainen
Mar 1, 1988·Acta paediatrica Scandinavica·I SandströmB Melen
Nov 1, 1986·Scandinavian Journal of Primary Health Care·F E Skjeldestad, A Dalen
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·I Sandström
Jun 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·B FriisJ T Grayston
Jan 1, 1995·The Journal of Laryngology and Otology·C A Shinkwin, K P Gibbin
Dec 22, 1999·Annals of Tropical Paediatrics·H J ZarD Hanslo
Dec 1, 1979·Archives of Andrology·H H Handsfield, W R Bowie
Sep 1, 1987·Annals of Tropical Paediatrics·D MabeyT Forsey
Apr 20, 2005·Neonatal Network : NN·Davita Hammer
Mar 1, 1984·Infection Control : IC·M F Rein
Jun 1, 1989·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A Hossain
May 1, 1988·Scandinavian Journal of Primary Health Care·F E Skjeldestad, A Dalen
Sep 1, 1984·Drug Intelligence & Clinical Pharmacy·E M Zola
Dec 24, 1997·Journal of Paediatrics and Child Health·Y F NgeowT C Quinn
Jan 1, 1993·Annals of Tropical Paediatrics·A SergiwaC A Hart
Feb 1, 1984·The Journal of Hygiene·J Nagington
Oct 3, 2020·Pediatrics in Review·Eleanor A Sharp, Jessica L Garrison
Dec 1, 2003·Paediatrics & Child Health·H Dele Davies
Apr 2, 1990·The Medical Journal of Australia·J Kariks
Jun 9, 1984·The Medical Journal of Australia·M F HarrisA Davidson

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Antibodies, Bacterial
Chlamydia Infections
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