Chlamydia trachomatis infection: implications for HPV status and cervical cancer

Archives of Gynecology and Obstetrics
Jani SilvaRui Medeiros

Abstract

Genital Chlamydia trachomatis (CT) infections have been identified as a major health problem concern. CT is associated with adverse effect on women reproduction and also associated with cervical hypertrophy and induction of squamous metaplasia, providing a possible relationship with human papillomavirus (HPV) infection. Infection by high-risk HPV types is crucial to the pathogenesis of invasive cervical cancer (ICC), but other co-variants/cofactors must be present for the development of malignancy. CT biological effect may damage the mucosal barrier, improving HPV infection, or may interfere in immune response and viral clearance supporting the persistence of HPV infection. Moreover, CT-related chronic cervical inflammation, decrease of lower genital tract antigen-presenting cells, inhibition of cell-mediated immunity, and anti-apoptotic capacity may influence the natural history of HPV infection, namely persistence progression or resolution. Although several epidemiological studies have stated a positive association involving CT and HPV-related cervical neoplastic lesions and/or cervical cancer (CC), the specific role of this bacterium in the pathogenesis of cervical neoplasia has not been completely clarified. The present rev...Continue Reading

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Citations

Apr 4, 2014·Archives of Gynecology and Obstetrics·Jani SilvaRui Medeiros
Feb 13, 2014·Archives of Gynecology and Obstetrics·Eddie Fernando Candido Murta
Jan 27, 2015·Infectious Agents and Cancer·Silva SeraceniManola Comar
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