Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice

Cellular Immunology
Ashlesh K MurthyBernard P Arulanandam

Abstract

Chlamydia trachomatis is an intracellular bacterial pathogen that primarily infects via mucosal surfaces. Using mice with a targeted disruption in IgA gene expression (IgA(-/-) mice), we have studied the contribution of IgA, the principal mucosal antibody isotype, in primary immune defenses against pulmonary C. trachomatis infection. Bacterial burden was comparable between IgA(-/-) and IgA(+/+) animals following C. trachomatis challenge. Serum and pulmonary anti-Chlamydia antibody levels were higher in IgA(-/-) animals, with the exception of IgA. Lung sections of challenged IgA(-/-) mice showed more extensive immunopathology than corresponding IgA(+/+) animals. Real-time PCR analysis demonstrated significantly greater IFN-gamma and TGF-beta mRNA expression in IgA(-/-) as compared to IgA(+/+) animals. Together, these results suggest that IgA may not be necessary for clearance of primary C. trachomatis infection. However, IgA(-/-) mice displayed exaggerated lung histopathology and altered cytokine production, indicating an important role for IgA in regulating C. trachomatis induced pulmonary inflammation and maintenance of mucosal homeostasis.

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Citations

Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Madhulika JupelliBernard P Arulanandam
Aug 17, 2006·Journal of Gastroenterology and Hepatology·Ashlesh K MurthyBernard P Arulanandam
Jan 13, 2016·Pathogens and Disease·Gopala Krishna Koundinya LankaBernard P Arulanandam
Jul 24, 2010·Vaccine·Kelly A CunninghamKenneth W Beagley
Mar 14, 2013·Cellular Microbiology·J H KimJ N Engel
Oct 19, 2007·Clinical and Vaccine Immunology : CVI·Weidang LiBernard P Arulanandam
Feb 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lili ChenGuangming Zhong
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Madhulika JupelliBernard P Arulanandam
Jun 30, 2019·PloS One·Tatiana GupalovaAlexander Suvorov
Mar 5, 2015·Infectious Diseases·Adel SepanjniaFatemeh Dahmardeh
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weidang LiBernard P Arulanandam
Feb 23, 2020·Microbes and Infection·Jonathon KeckBernard P Arulanandam

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