PMID: 9529043Apr 7, 1998Paper

Chlamydial infection in inducible nitric oxide synthase knockout mice

Infection and Immunity
J U IgietsemeHarlan D Caldwell

Abstract

Type 1 CD4+-T-cell-mediated immunity is crucial for the resolution of chlamydial infection of the murine female genital tract. Previous studies demonstrating a correlation between CD4+-T-cell-mediated inhibition of chlamydial growth and gamma interferon (IFN-gamma)-mediated induction of nitric oxide synthase suggested a potential role for the nitric oxide (NO) effector pathway in the clearance of Chlamydia from genital epithelial cells by the immune system. To clarify the role of this pathway, the growth levels of Chlamydia trachomatis organisms in normal (iNOS+/+) mice and in genetically engineered mice lacking the inducible nitric oxide synthase (iNOS) gene (iNOS-/- mice) were compared. There was no significant difference in the course of genital chlamydial infections in iNOS+/+ and iNOS-/- mice as determined by recovery of Chlamydia organisms shed from genital epithelial cells. Dissemination of Chlamydia to the spleen and lungs occurred to a greater extent in iNOS-/- than in iNOS+/+ mice, which correlated with a marginal increase in the susceptibility of macrophages from iNOS-/- mice to chlamydial infection in vitro. However, infections were rapidly cleared from all affected tissues, with no clinical signs of disease. The fi...Continue Reading

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Citations

Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M E RottenbergH Wigzell
Mar 29, 2000·Scandinavian Journal of Immunology·C SvanholmM E Rottenberg
Oct 18, 2000·Infection and Immunity·W A DayL A Joens
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Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Krupakar JayarapuRaymond M Johnson
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Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toni DarvilleDavid M Ojcius
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BenoitJean-Louis Mege
Apr 15, 2015·Infection and Immunity·Carrie E LaskyCharles R Brown
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May 16, 2002·Infection and Immunity·Richard P Morrison, Harlan D Caldwell
Mar 23, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph U IgietsemeHarlan D Caldwell
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