Chlamydomonas Basal Bodies as Flagella Organizing Centers

Cells
Jenna Lynne Wingfield, Karl-Ferdinand Lechtreck

Abstract

During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery.

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Citations

Nov 23, 2018·Essays in Biochemistry·Kirsty Y Wan
Jul 13, 2019·Cells·Vladimir Joukov, Arcangela De Nicolo
Sep 12, 2020·Cellular and Molecular Life Sciences : CMLS·Lance Lee, Lawrence E Ostrowski
Feb 8, 2021·Bio Systems·František Baluška, Sherrie Lyons
Jan 19, 2021·Seminars in Cell & Developmental Biology·Swadhin Chandra Jana
Jun 16, 2021·Microbiological Research·Francisco Alejandro Lagunas-RangelRosa María Bermúdez-Cruz
Aug 19, 2021·Journal of Cell Science·Robert Mahen
Oct 23, 2020·Biophysical Journal·Di JinOttavio A Croze
Dec 20, 2021·Seminars in Cell & Developmental Biology·Ewa Joachimiak, Dorota Wloga
Jan 13, 2022·The Plant Cell·Eva Laura von der Heyde, Armin Hallmann

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Methods Mentioned

BETA
acetylation
amputation
fluorescence recovery after photobleaching
GTPase

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