Chlamydophila pneumoniae inhibits differentiation of progenitor adipose cells and impairs insulin signaling

The Journal of Infectious Diseases
Yu ShiPeter P Liu

Abstract

Recent clinical studies have shown Chlamydophila pneumoniae seropositivity to be related to overweight status and inversely related to insulin sensitivity. The present study was performed to investigate the potential effects of C. pneumoniae infection of adipocytes. 3T3-L1 cells and primary epididymal preadipocytes were infected with C. pneumoniae either before or after induction of differentiation, and the effects on adipogenesis and insulin signaling were determined. Tumor necrosis factor (TNF)-alpha signaling was examined by assessing the effects of C. pneumoniae infection in preadipocytes isolated from epididymal adipose tissue of both wild-type and TNF-alpha(-/-) mice. C. pneumoniae successfully infected both undifferentiated and differentiated 3T3-L1 cells in vitro. The bacteria were also detected in adipose tissue of infected low-density lipoprotein receptor-deficient mice. TNF-alpha protein levels were significantly increased in cells infected with either live or heat-killed C. pneumoniae or treated with lipopolysaccharide or heat-shock protein 65; this increase was associated with inhibition of adipocyte differentiation and down-regulation of insulin-stimulated tyrosine-phosphorylated insulin receptor and its substrate...Continue Reading

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Dec 19, 2009·Epidemiology and Infection·A RantalaP Saikku
Jan 6, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Jaworowska, G Bazylak
Jul 1, 2010·BMC Complementary and Alternative Medicine·Pratibha V NerurkarVivek R Nerurkar

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