Chlamyphilone, a Novel Pochonia chlamydosporia Metabolite with Insecticidal Activity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Federica LacatenaF Vinale

Abstract

Metabolites from a collection of selected fungal isolates have been screened for insecticidal activity against the aphid Acyrthosiphon pisum. Crude organic extracts of culture filtrates from six fungal isolates (Paecilomyces lilacinus, Pochonia chlamydosporia, Penicillium griseofulvum, Beauveria bassiana, Metarhizium anisopliae and Talaromyces pinophilus) caused mortality of aphids within 72 h after treatment. In this work, bioassay-guided fractionation has been used to characterize the main bioactive metabolites accumulated in fungal extracts. Leucinostatins A, B and D represent the bioactive compounds produced by P. lilacinus. From P. griseofulvum and B. bassiana extracts, griseofulvin and beauvericin have been isolated, respectively; 3-O-Methylfunicone and a mixture of destruxins have been found in the active fractions of T. pinophilum and M. anisopliae, respectively. A novel azaphilone compound, we named chlamyphilone, with significant insecticidal activity, has been isolated from the culture filtrate of P. chlamydosporia. Its structure has been determined using extensive spectroscopic methods and chemical derivatization.

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Apr 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Michela SalvatoreAnna Andolfi

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Methods Mentioned

BETA
column chromatography
NMR
PCR

Software Mentioned

SPSS
Agilent MassHunter Data Acquisition
Bruker Topspin
MM
MassHunter Qualitative Analysis

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