Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Mingliang FanBizhi Shi

Abstract

Self-assembly of anticancer small molecules into nanostructures may represent an attractive approach to improve the treatment of experimental solid tumors. As a proof of concept, we designed and synthesized the conjugate prodrug of hydrophilic gemcitabine by its covalent coupling to hydrophobic chlorambucil via a hydrolyzable ester linkage. The resulting amphiphilic conjugates self-assembled into nanoparticles in water and exhibited significant anticancer activity in vitro against a variety of human cancer cells. In vivo anticancer activity of these nanoparticles has been tested on subcutaneous grafted SMMC-7721 hepatocellular carcinoma model. Such chlorambucil gemcitabine conjugate nanomedicine should have potential applications in cancer therapy.

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Citations

Jun 23, 2016·Drug Discovery Today·Gaia FumagalliDaniele Passarella
Oct 22, 2016·Biomaterials·Si-Yong QinXian-Zheng Zhang
Mar 12, 2019·Current Drug Metabolism·Hany A Abdel SamieMohammad A Kamal
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Mar 9, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ai-Mei LiaoChangJu Chun

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