Chloramphenicol in the treatment of enteric fever

Transactions of the Royal Society of Tropical Medicine and Hygiene
C Herzog, A M Geddes

Abstract

Chloramphenicol is still very effective for acute enteric fever. A literature survey does not confirm the repeated claims of decreasing efficacy over the past 20 years (not taking into account the R factor mediated resistance noted since 1972/73). However, there have been regional variations in the time needed to achieve defervescence under chloramphenicol treatment since the early 1950s. When comparing alternative antimicrobials with chloramphenicol other criteria apart from clinical efficacy have to be considered, namely, influence on the rate of excretion of the organisms and the relapse rate, ease of administration parenterally, toxicity, cost, and the possible occurrence of resistance to Salmonella typhi or S. paratyphi A/B.

References

Jan 1, 1978·The American Journal of the Medical Sciences·D H Lawson, H Jick
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·T ButlerM M Muoi
Sep 1, 1977·The Journal of Antimicrobial Chemotherapy·A M Geddes
Aug 15, 1981·Lancet·V M RangnekarH I Jhala
Jan 31, 1981·British Medical Journal·M W McKendrickI D Farrell
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·E D Mukhtar, M O Mekki

❮ Previous
Next ❯

Citations

Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Zavala TrujilloM Renteria
Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·P S Sarma, P Durairaj
Mar 1, 1994·Antimicrobial Agents and Chemotherapy·E GotuzzoH L DuPont
Oct 1, 1985·Tropical Doctor·G C Cook

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.