Chloramphenicol inhibition of the bactericidal effect of ampicillin against Haemophilus influenzae.

Antimicrobial Agents and Chemotherapy
V Rocco, G Overturf

Abstract

The effects of combinations of ampicillin and chloramphenicol against seven strains of Haemophilus influenzae type b (five beta-lactamase-negative and two beta-lactamase-positive strains) were evaluated by killing-kinetic methods. Growth of strains was assessed in modified Levinthal broth against an inoculum of 10(5) organisms per ml; colony counts were performed immediately and at 6 and 20 h postinoculation. Ampicillin and chloramphenicol were completely bactericidal at 20 h. reducing bacterial densities to 0 colony-forming units per ml at concentrations equivalent to the ampicillin inhibitory concentration and twofold the chloramphenicol inhibitory concentrations. Chloramphenicol at its inhibitory concentration or at one-half of its inhibitory concentration prevented the normally bactericidal activity of ampicillin at 20 h incubation, but not at 6 h.

References

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Nov 1, 1974·Antimicrobial Agents and Chemotherapy·C Thornsberry, L A Kirven

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Citations

Mar 1, 1983·Antimicrobial Agents and Chemotherapy·V SchaufL Riff
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·A M Mackenzie, F T Chan
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·J R LapointeJ H Joncas
Jan 8, 2014·Expert Review of Anti-infective Therapy·Rok ČivljakNicola Petrosillo
Jun 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michael A LobritzJames J Collins
Jun 19, 2019·The Journal of Antimicrobial Chemotherapy·Yuan LiuZhiqiang Wang
Feb 16, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Hayk Minasyan
Jul 8, 2019·Cell Metabolism·Jonathan M StokesJames J Collins

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