PMID: 6411480Jan 1, 1983Paper

Chloramphenicol pharmacokinetics in Ethiopian children of differing nutritional status

European Journal of Clinical Pharmacology
M ErikssonT W Mariam

Abstract

The pharmacokinetics of i.v. chloramphenicol succinate and oral chloramphenicol palmitate were studied in Ethiopian children with different nutritional states. In children with kwashiorkor the plasma clearance of chloramphenicol was significantly lower than in children of normal weight (4.16 ml/min/kg versus 7.53 ml/min/kg). In consequence the mean half-life was prolonged (3.76 h versus 2.85 h) and this led to somewhat higher plasma levels in the kwashiorkor children. The influence of the pathophysiological changes offset one another so that plasma concentrations within the therapeutic range were obtained in children with kwashiorkor given recommended standard i.v. doses. The absorption of chloramphenicol after oral administration in severely malnourished children was erratic, which suggests that this route should be avoided in such patients.

References

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·M AshtonL Paalzow
Nov 1, 1994·Indian Journal of Pediatrics·R BahlM K Bhan
Jun 17, 2010·European Journal of Clinical Pharmacology·Kazeem A OshikoyaImti Choonara
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
Jan 1, 1991·Pharmacology & Therapeutics·J O Miners, P I Mackenzie
Apr 1, 1995·Pharmacology & Toxicology·P BolmeT Woldemariam
Dec 3, 2009·Nutrition & Metabolism·Kazeem A Oshikoya, Idowu O Senbanjo
Aug 13, 2011·Bulletin of the World Health Organization·Marzia Lazzerini, David Tickell
Jul 15, 2015·Expert Opinion on Drug Metabolism & Toxicology·Tran H TranRobert A Mangione
Nov 1, 1988·Acta paediatrica Scandinavica·M ErikssonL Paalzow
May 26, 2017·The Journal of Infectious Diseases·Samuel L M ArnoldWesley C Van Voorhis
Apr 29, 2000·Public Health Nutrition·F Vio, C Albala
Aug 1, 1989·British Journal of Clinical Pharmacology·L A SalakoF O Akinbami
Aug 30, 2005·Journal of Tropical Pediatrics·Gilbert O KokwaroCharles R J C Newton

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