Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs

Veterinary Anaesthesia and Analgesia
B KuKanich, K KuKanich

Abstract

To assess the effects of cytochrome P450 (CYP) inhibitors (ketoconazole, chloramphenicol, trimethoprim, fluoxetine, cimetidine and medetomidine) in various combinations on the pharmacokinetics of oral methadone in Greyhound dogs to determine the specific effects of the different inhibitors and if a clinically relevant interaction occurs. Non-randomized, sequential design. Six healthy Greyhound dogs (three male, three female). Canine CYP inhibitors (ketoconazole, chloramphenicol, trimethoprim, fluoxetine, cimetidine and medetomidine) were administered in varying combinations prior to the administration of oral methadone. Plasma was obtained from each dog to enable the determination of methadone and CYP inhibitor drug concentrations using liquid chromatography with either mass spectrometry or ultraviolet detection. Significant increases in the area under the curve (AUC) and maximum plasma concentrations (CMAX ) of methadone occurred in all groups administered chloramphenicol. The AUC (6 hours ng mL(-1)) and CMAX (6 ng mL(-1)) of methadone significantly increased to 541 hours ng mL(-1) and 47.8 ng mL(-1), respectively, when methadone was administered with chloramphenicol as a sole inhibitor. There were no significant effects of CY...Continue Reading

References

Jan 1, 1994·Chirality·N SchmidtG Geisslinger
Aug 3, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B L Hay KrausM H Court
Jan 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·Ping LuMagang Shou
May 10, 2006·Biochemistry·Alena SiarheyevaClemens Glaubitz
Oct 6, 2007·American Journal of Veterinary Research·Chadwick L West, Katrina L Mealey
Feb 20, 2008·Veterinary Anaesthesia and Analgesia·Butch KuKanich, Stacy L Borum
May 2, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Divesh AidasaniCharles W Locuson
Dec 19, 2009·Veterinary Anaesthesia and Analgesia·Carina Ingvast-LarssonKerstin Olsson
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·M T BarattaC W Locuson
Sep 16, 2010·Journal of Veterinary Pharmacology and Therapeutics·K L MealeyF R Nelson
Mar 21, 2012·Journal of Veterinary Pharmacology and Therapeutics·R L LinardiF M Andrews

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