PMID: 2485205Jan 1, 1989Paper

Chlordecone-induced follicular toxicity in mouse ovaries

Reproductive Toxicology
W J Swartz, G M Mall

Abstract

The effect of the pesticide, chlordecone, on murine follicular development was examined. Female CD-1 mice were exposed to chlordecone for 5 consecutive days for each of 4 consecutive weeks (0.25 mg/day). Controls received sesame oil vehicle or estradiol-17 beta (E-17 beta; 0.1 mg/day) since chlordecone has been ascribed estrogenic activity. Animals were sacrificed 24 h following the final exposure. Ovaries were removed, serially sectioned, and stained. Follicles were classified as small, medium, or large and were tabulated. Twice as many medium-sized follicles were found in the E-17 beta-treated mice as in both the chlordecone-exposed and sesame oil control groups. Both pesticide- and E-17 beta-exposed mice displayed a much higher percent of atresia in the large follicles; however, there were more actual healthy, large follicles in the E-17 beta group. Thus, both chlordecone and E-17 beta induced increased atresia among large follicles, which could be due to the estrogenicity of these agents. However, a decreased pool of healthy large- and medium-sized follicles occurred in chlordecone-treated mice, a condition not seen in E-17 beta-treated mice. Thus, the pool of potentially ovulatory follicles is reduced in the pesticide-trea...Continue Reading

References

Jan 1, 1977·Journal of Toxicology and Environmental Health·J A McLachlan
Aug 13, 1971·Science·W L HeinrichsN L Lawrence
Dec 1, 1968·Journal of Reproduction and Fertility·T Pedersen, H Peters
Sep 1, 1969·Toxicology and Applied Pharmacology·L Z McFarland, P B Lacy
Aug 1, 1965·Journal of Economic Entomology·E E GoodD F Miller
Jul 1, 1965·Toxicology and Applied Pharmacology·J J Huber
Aug 1, 1964·Biological Reviews of the Cambridge Philosophical Society·A M MANDL
Jul 1, 1950·The Journal of Endocrinology·A M MANDL, S ZUCKERMAN
Jun 1, 1951·The Journal of Endocrinology·A M MANDL, S ZUCKERMAN
Sep 3, 1971·Science·W L HeinrichsN L Lawrence

❮ Previous
Next ❯

Citations

Dec 16, 1996·Toxicology Letters·R C MurthyD K Saxena
Oct 29, 2002·Reproductive Toxicology·M B Hiremath, B B Kaliwal
Jun 2, 2006·Reproductive Biology and Endocrinology : RB&E·Reini W BretveldNel Roeleveld
Jan 1, 1997·Journal of Basic and Clinical Physiology and Pharmacology·I Asmathbanu, B B Kaliwal
Jan 13, 2000·Journal of Basic and Clinical Physiology and Pharmacology·U C Jadarmkunti, B B Kaliwal
Apr 3, 2003·Journal of Basic and Clinical Physiology and Pharmacology·M P Mahadevaswami, B B Kaliwal
May 20, 2003·Journal of Basic and Clinical Physiology and Pharmacology·M B Hiremath, B B Kaliwal
Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·N D KoçM N Muşlu
May 1, 1995·Psychiatry and Clinical Neurosciences·C Mundt
Jun 12, 2008·Industrial Health·Raghavendra L Ksheerasagar, Basappa B Kaliwal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.