Chlordecone (Kepone)-potentiated carbon tetrachloride hepatotoxicity in partially hepatectomized rats--a histomorphometric study.

Journal of Applied Toxicology : JAT
P R KodavantiV G Lockard

Abstract

Our previous studies indicated the involvement of some unidentified mechanisms, apart from the bioactivation phenomenon, in chlordecone (CD)-potentiated CCl4 hepatotoxicity and lethality. Recent studies revealed that hepatocellular regeneration is suppressed in CD + CCl4 toxicity. The present work is a continuation of our earlier work employing a partial hepatectomy model for stimulating hepatocellular division, in normal (N) or CD-treated (10 ppm for 15 days) rats. Male Sprague-Dawley rats maintained on an appropriate dietary protocol and undergoing sham (SH) or partial hepatectomies (PH) were employed. Hepatocellular regeneration was assessed by measuring the percentage mitotic figures and by autoradiography of liver sections from rats given 3H-thymidine in vivo. Hepatotoxicity was assessed by examining liver sections for necrotic cells, swollen cells and cells having lipid droplets. CCl4 (100 microliters kg-1)-induced histopathological alterations in CD-pretreated rats were significantly decreased in rats 2 days post-PH (PH2) as compared to SH rats or rats 7 days post-PH (PH7), indicating that amplification of CCl4 toxicity is significantly reduced when there is a greater regenerative activity. The percentage of mitoses as w...Continue Reading

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Citations

Jan 1, 1993·Archives of Toxicology·V C Rao, H M Mehendale
Jan 1, 1991·The International Journal of Biochemistry·M G Soni, H M Mehendale
Mar 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E J Calabrese, H M Mehendale
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H M Mehendale, S D Ray
Oct 1, 1991·Journal of Toxicology and Environmental Health·D DesaiahB S Sekhon
Apr 5, 2005·Toxicologic Pathology·Harihara M Mehendale
Jun 1, 1994·Journal of Biochemical Toxicology·H M MehendaleC V Rao
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R KodavantiH M Mehendale
Jan 1, 1991·Toxicologic Pathology·V C Rao, H M Mehendale
Mar 15, 1991·Toxicology and Applied Pharmacology·M G Soni, H M Mehendale

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