PMID: 15348518Sep 7, 2004Paper

Chlorhexidine-containing mucoadhesive polymeric compacts designed for use in the oral cavity: an examination of their physical properties, in vitro/in vivo drug release properties and clinical acceptability

Journal of Materials Science. Materials in Medicine
C R IrwinDavid S Jones

Abstract

This study describes the formulation, physicochemical and mucoadhesive properties and in in vitro/in vivo release of chlorhexidine from mucoadhesive, polymeric compacts, designed for application within the oral cavity. Compacts were prepared by direct compression of mixtures containing 100 mg sodium carboxymethylcellulose (NaCMC), 25 mg hydroxyethylcellulose (HEC)/75 mg polyacrylic acid (PAA) and 75 mg HEC/25 mg PAA. The mechanical and mucoadhesive properties of the drug-loaded compacts were examined using a texture analyzer in compression and tension modes, respectively. Evaluation of mucoadhesion was performed using a mucin-coated gauze substrate. In vitro release of chlorhexidine was performed under sink conditions (phosphate buffered saline, pH 7.0, 37 degrees C) using a Caleva 7ST dissolution apparatus. Salivary chlorhexidine levels were determined following intra-oral placement of drug-containing formulations. Quantification of the mass of chlorhexidine released both in vitro and in vivo was performed using HPLC with ultraviolet detection. Furthermore, the in vivo acceptability of the various polymeric compacts was assessed in volunteers using standard questionnaires. Compacts composed of HEC/PAA exhibited greater in vivo...Continue Reading

Citations

Oct 29, 2013·Pharmaceutical Development and Technology·M Keshavarz, B Kaffashi
Apr 5, 2014·Journal of Materials Science. Materials in Medicine·Kajal GhosalBenoy Brata Bhowmik
Dec 29, 2013·Drug Development and Industrial Pharmacy·Muge KilicarslanRoland Bodmeier
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·Katarina Edsman, Helene Hägerström
Sep 11, 2019·International Journal of Pharmaceutics·Rania HamedRana Abu-Huwaij

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