Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive

Journal of Dentistry
Huiyi YanCui Huang

Abstract

This work aims to explore the feasibility of chlorhexidine-encapsulated mesoporous silica (CHX@pMSN) as a modifier of a commercial dental adhesive via the evaluation of physicochemical properties and antibacterial capabilities of adhesive-dentin interface. Therapeutic adhesives were developed in the present study by incorporating CHX@pMSN into a commercial adhesive at four mass fractions (0, 1, 5 and 10 wt.%). The antibacterial capability on Streptococcus mutans (S. mutans) biofilm, conversion degree, adhesive morphology, microtensile bond strength (MTBS) and nanoleakage expression were evaluated comprehensively. MTT and CLSM evaluation showed that CHX@pMSN-doped adhesive inhibits S. mutans biofilm growth, while CHX is released from the modified adhesive continuously. The incorporation of CHX@pMSN did not affect immediate bond strength at the concentration of 1% and 5% (P >  0.05). Moreover, these bonds were mainly preserved in 5% CHX@pMSN group after one month of collagenase ageing. Meanwhile, CHX@pMSN-doped adhesive groups exhibited similar nanoleakage distribution compared with the control. This study showed that the 5% CHX@pMSN-modified adhesive achieved balance amongst unaffected immediate bonding strength, well-preserved ...Continue Reading

Citations

Apr 17, 2020·Journal of Dental Research·F YuJ H Chen
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zohaib AkramAmr S Fawzy
Apr 4, 2021·Polymers·Louis HardanCarlos Enrique Cuevas-Suárez
Apr 21, 2021·Stomatologii︠a︡·A V Blinova, V A Rumyantsev
Dec 18, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Milena CadenaroLorenzo Breschi

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