Chlorhexidine with or without alcohol against biofilm formation: efficacy, adverse events and taste preference

Brazilian Oral Research
Gabriela Otero Dos SantosPatricia Weidlich

Abstract

In recent years, different chlorhexidine formulations have been tested, including an alcohol-free alternative, but the effect of this solution on early biofilm formation is not clear. A crossover, randomized, double-blind clinical trial was conducted to evaluate the effect of two chlorhexidine solutions against supra- and subgingival biofilm formation (NCT#02656251). Thirty-five participants were randomized and asked to rinse twice daily with 15 ml of an alcohol-containing 0.12% chlorhexidine solution, an alcohol-free 0.12% chlorhexidine solution, or placebo. The study was conducted in three experimental periods of 4 days each, with a 10-day washout between the periods. All the experimental periods followed the same protocol, except that the solutions were switched. Biofilm distribution was evaluated every 24 hours by the Plaque-Free Zone Index, during 96 hours. Adverse events were self-reported and sensory evaluation was performed using a hedonic scale. Compared to the placebo, the chlorhexidine solutions resulted in a significantly higher number of surfaces free of plaque over 96 hours (p < 0.01), and were able to prevent subgingival biofilm formation (p < 0.01). The alcohol-free chlorhexidine solution was associated with a l...Continue Reading

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Citations

Oct 29, 2019·The Journal of Clinical Pediatric Dentistry·Eman Abu-ObaidSayed Auda
Apr 9, 2021·International Journal of Dental Hygiene·María Del Rosario Ruiz NúñezAna Lúcia Schaefer Ferreira de Mello
May 4, 2021·The Bone & Joint Journal·Jeffrey A O'DonnellThorsten M Seyler
Nov 28, 2020·ACS Infectious Diseases·Susana I C RicardoIsabel A C Ribeiro
Dec 18, 2021·Evidence-based Dentistry·Shipra GuptaMohita Singla

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