Chloride-enhanced atmospheric pressure chemical ionization mass spectrometry of polychlorinated n-alkanes

Rapid Communications in Mass Spectrometry : RCM
Zdenek Zencak, Michael Oehme

Abstract

The use of high-performance liquid chromatography combined with chloride-enhanced atmospheric pressure chemical ionization for the determination of polychlorinated n-alkanes (PCAs, also called chlorinated paraffins or CPs) is described as an alternative to gas chromatographic methods. Atmospheric pressure chemical ionization in the negative ion mode formed exclusively [M+Cl](-) adduct ions and suppressed fragmentation when a chlorinated solvent was added. Limits of detection were 1-2 ng/microL for technical PCA mixtures. Response factors for single short-chain PCA homologues with different degrees of chlorination varied by not more than a factor of 6.5. The developed method was applied for the determination of the composition of technical PCA mixtures as well as for the analysis of PCAs in household commodities. Medium-chain PCAs were found in paint samples at concentrations of 8.2-11.5% (w/w), compared with 7.4-11.5% obtained by gas chromatography combined with electron ionization tandem mass spectrometry.

References

Jun 24, 2003·Rapid Communications in Mass Spectrometry : RCM·Wesley Budakowski, Gregg Tomy
Jul 25, 2003·Journal of Chromatography. a·Heiko Hayen, Uwe Karst
Aug 26, 2003·Analytical and Bioanalytical Chemistry·Suze M van LeeuwenUwe Karst

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Citations

Sep 1, 2006·Analytical and Bioanalytical Chemistry·F J SantosM T Galceran
Feb 12, 2013·Journal of the American Society for Mass Spectrometry·Robert B Cody, A John Dane
Sep 19, 2008·Journal of Chromatography. a·Risto Kostiainen, Tiina J Kauppila
Jul 4, 2006·Environment International·Stéphane BayenGareth O Thomas
Nov 9, 2016·Journal of the American Society for Mass Spectrometry·Isra HassanAthula B Attygalle
Aug 30, 2007·Journal of Environmental Monitoring : JEM·Francesca PellizzatoHendrik Emons
Aug 17, 2017·Environmental Science & Technology·Bo YuanCynthia A de Wit

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