Chloride requirement for monoamine transporters

Pflügers Archiv : European journal of physiology
L J De Felice

Abstract

This review focuses on the Cl(-) requirement for dopamine, serotonin, and norepinephrine (DA, 5-HT, and NE) transport and induced current via the transporters for these transmitters, DAT, SERT, and NET. Indirect evidence exists for the passage of Cl(-) ions through monoamine transporters; however, direct evidence is sparse. An unanswered question is why in some preparations, notably native neurons, it appears that Cl(-) ions carry the current through DAT, whereas in heterologous expression systems Na(+) ions carry the current often referred to as the uncoupled current. It is suggested that different functional states in monoamine transporters represent conformational states that carry dominantly Cl(-) or Na(+). Structures of monoamine transporters contribute enormously to structure-function relationships; however, thus far no structural features support the functionally relevant ionic currents that are known to exist in monoamine transporters.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G Rudnick, S C Wall
Sep 1, 1995·Neuron·J I WadicheM P Kavanaugh
Jul 28, 1995·The Journal of Biological Chemistry·R J VandenbergM P Kavanaugh
May 1, 1995·Neuron·J I WadicheM P Kavanaugh
Sep 1, 1994·Journal of Neuroscience Research·M SitgesL M Chiu
Apr 1, 1994·Neuron·S MagerH A Lester
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L DemchyshynH B Niznik
Jul 26, 1996·The Journal of Biological Chemistry·H H GuG Rudnick
Feb 1, 1996·Biophysical Journal·H P LarssonH Lecar
Feb 1, 1996·Biophysical Journal·A SuH A Lester
Nov 1, 1996·Neuron·H A LesterS Mager
Jul 22, 1998·Journal of Bioenergetics and Biomembranes·G Rudnick
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·A GalliL J DeFelice
Sep 28, 2002·Nature Neuroscience·Susan L IngramSusan G Amara
Dec 24, 2002·Biophysical Journal·Scott V Adams, Louis J DeFelice
Jan 4, 2003·Nature Reviews. Neuroscience·Gonzalo E TorresMarc G Caron
Apr 12, 2003·Trends in Neurosciences·David Sulzer, Aurelio Galli
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lucia CarvelliLouis J Defelice
Mar 11, 2005·The Journal of Biological Chemistry·Joel W SchwartzLouis J DeFelice
Apr 4, 2006·Biochemical and Biophysical Research Communications·Howard H GuDawn D Han
Oct 25, 2006·Annual Review of Physiology·Louis J DeFelice, Tapasree Goswami
Mar 3, 2007·Molecular Pharmacology·Randy D Blakely, Louis J DeFelice
Apr 10, 2007·The Journal of Membrane Biology·Gary Rudnick
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lucy R ForrestBarry Honig

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Citations

Mar 30, 2019·Angewandte Chemie·Glenn GrauwelsKristin Bartik
Feb 8, 2019·Journal of Biomolecular Structure & Dynamics·Mert GurElhan Taka
Jul 25, 2018·Current Protocols in Pharmacology·Shubha Gururaja RaoHarpreet Singh

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