Chlorimipramine--but not imipramine--rapidly reduces [3H]imipramine binding in human platelet membranes

European Journal of Pharmacology
E T Mellerup, P Plenge

Abstract

A single dose of 50 mg chlorimipramine was followed by a rapid and pronounced decrease in [3H]imipramine binding to platelet membranes. Incubation of human platelets or platelet membranes with 25 nM chlorimipramine similarly reduced [3H]imipramine binding. Imipramine, desmethylchlorimipramine, chlorpromazine and some serotonin uptake inhibitors did not have this effect. The effect was not due to chlorimipramine remaining in the membranes during the binding analysis.

References

Dec 23, 1983·European Journal of Pharmacology·E T MellerupM Engelstoft
Oct 1, 1982·Psychiatry Research·E T MellerupR Rosenberg

❮ Previous
Next ❯

Citations

Feb 15, 1988·Experientia·S Z Langer, A M Galzin
Sep 1, 1991·Biological Psychiatry·S W KimJ M Davis
Sep 1, 1994·Biological Psychiatry·P M Ellis, C Salmond
Aug 1, 1991·Journal of Affective Disorders·E SzádóczkyE Moussong-Kovács
Nov 1, 1988·Psychiatry Research·E T MellerupP Plenge
Apr 1, 1990·Psychiatry Research·E T MellerupS Schepelern
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Z Langer, H Schoemaker
Nov 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·B BirmaherH Rabinovich
Oct 1, 1990·Acta Psychiatrica Scandinavica·E T Mellerup, P Plenge
Aug 1, 1988·Acta Psychiatrica Scandinavica·P PlengeA Gjerris
Aug 1, 1992·Acta Psychiatrica Scandinavica·P M EllisR R Cooke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here