Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model

Cancer Letters
William Wei Lim ChinMalini Olivo

Abstract

The use of fluorescence diagnosis as a modern cancer diagnostic modality is rapidly gaining importance in the field of urology. It is based on the detection of distinctive light emission of tissues sensitized by fluorescent dyes, commonly referred to as photosensitizers, after irradiation with a specific light source. Therefore, the search for specific fluorescent dyes with high sensitivity and specificity for bladder cancer is constantly being sought after. The aim of this study is to investigate the use of a new formulation consisting a mixture of chlorin e6 and polyvinylpyrrolidone (Ce6-PVP) for the detection of human bladder cancer cells (MGH) implanted on the chick chorioallantoic membrane (CAM) model. Uptake kinetics studies were quantitatively determined for both systemic and topical administrations of Ce6-PVP to the normal CAM as well as the MGH human bladder tumor implanted on CAM using fluorescence imaging technique. Rapid elimination of Ce6-PVP was displayed following topical application compared to systemic administration in the normal CAM system. Ce6-PVP was found to localize selectively in the xenografted bladder tumor in contrast to the CAM tissue. Neither dark toxicity nor irritancy was observed on the CAM tissu...Continue Reading

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Citations

Nov 2, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·William Wei Lim ChinMalini Olivo
Feb 16, 2011·Chemical Communications : Chem Comm·Bo Reum LeeEun Seong Lee
Sep 4, 2012·International Journal of Molecular Sciences·Rica BoscencuLuís Filipe Vieira Ferreira
Aug 21, 2014·Angiogenesis·Patrycja Nowak-SliwinskaM Luisa Iruela-Arispe
Jul 30, 2008·Drug Development and Industrial Pharmacy·Constance L L SawCeline V Liew
Aug 18, 2009·Photodiagnosis and Photodynamic Therapy·Asta Juzeniene
May 6, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gihan MahmoudUdo Bakowsky
Apr 3, 2012·Journal of Biomedical Optics·Tim N FordJerome Mertz
Aug 21, 2015·The Journal of Physical Chemistry. B·Marianne HädenerMartina Vermathen
Mar 18, 2006·Journal of Photochemistry and Photobiology. B, Biology·William Wei Lim ChinMalini Olivo
Nov 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karunya Albert, Hsin-Yun Hsu
Sep 8, 2017·Tissue Engineering. Part C, Methods·Inés Moreno-JiménezRichard O C Oreffo
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Jul 12, 2017·Scientific Reports·Benedict JefferiesPhilipp Mayer-Kuckuk
Dec 23, 2020·Photodiagnosis and Photodynamic Therapy·Rui LiuYuping Suo

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