PMID: 9163653May 1, 1997Paper

Chlorine gas induced acute lung injury in isolated rabbit lung

The European Respiratory Journal
A MenaouarF A Grimbert

Abstract

This study was designed to investigate the pathogenesis of chlorine gas (Cl2) induced acute lung injury and oedema. Isolated blood-perfused rabbit lungs were ventilated either with air (n=7) or air plus 500 parts per million (ppm) of Cl2 (n=7) for 10 min. Capillary pressure, measured by analysing the pressure/time transients of pulmonary arterial, venous and double (both arterial and venous) occlusions, was unchanged in both groups. In Cl2-exposed lungs, the fluid filtration rate increased from -0.228+/-0.25 to 1.823+/-1.23 mL min(-1) x 100 g(-1) (p<0.001) and the filtration coefficient increased from 0.091+/-0.01 to 0.259+/-0.07 mL x min(-1) x cmH2O(-1) x 100 g(-1) (p<0.001). No changes were observed in the control lungs. The extravascular lung water/blood-free dry weight ratio was 8.6+/-1.6 in the Cl2 group and 4.0+/-0.5 in the control group (p<0.001), confirming that the increase in lung weight was related to accumulation of extravascular fluid. Although the alveolar flooding by oedema is explained, in part, by the Cl2-induced epithelial injury, our results suggest that Cl2 exposure induces acute lung injury and oedema due to an increased microvascular permeability.

Citations

Dec 31, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·David BraccoRedouane Bouali
Sep 8, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gary W HoyleRoy J Rando
May 12, 2006·The Journal of Trauma·Andriy I BatchinskyLeopoldo C Cancio
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·S BayatF A Grimbert
May 2, 2003·American Journal of Respiratory and Critical Care Medicine·James G MartinKarim Maghni
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Jul 6, 2010·Proceedings of the American Thoracic Society·Gary W Hoyle
Jul 6, 2010·Proceedings of the American Thoracic Society·Carl W White, James G Martin
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May 3, 2006·Pediatric Emergency Care·Rais Vohra, Richard F Clark
Oct 23, 2009·Critical Care : the Official Journal of the Critical Care Forum·Raphael BriotFrancis Grimbert
Jun 16, 2016·Annals of the New York Academy of Sciences·Matthew CarlisleSadis Matalon
Jul 30, 2020·Annals of the New York Academy of Sciences·Jared RadbelHoward M Kipen

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