Chloroform extract of aged black garlic attenuates TNF-α-induced ROS generation, VCAM-1 expression, NF-κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells

Phytotherapy Research : PTR
Eun Na LeeSik Yoon

Abstract

Aged black garlic is a type of fermented garlic (Allium sativum) which has been used in Oriental countries for a long time because of various biological properties of garlic derivatives. The current study explored the potential of the chloroform extract of aged black garlic (CEABG) in attenuating the activities of adhesion molecules in tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). The study was performed on HUVECs that were pretreated with 30 μg/mL of CEABG before TNF-α treatment. Treatment of HUVECs with CEABG significantly inhibited TNF-α-induced reactive oxygen species (ROS) formation. HUVECs treated with CEABG showed markedly suppressed TNF-α-induced mRNA expression of VCAM-1, but little alteration in ICAM-1 and E-selectin mRNA expression. CEABG treatment also significantly decreased the TNF-α-induced cell surface and total protein expression of VCAM-1 without affecting ICAM-1 and E-selectin expression. In addition, treatment of HUVECs with CEABG markedly reduced THP-1 monocyte adhesion to TNF-α-stimulated HUVECs. Furthermore, CEABG significantly inhibited NF-κB transcription factor activation in TNF-α-stimulated HUVECs. The data provide new evidence of the antiinflammatory prop...Continue Reading

References

Apr 1, 1996·FEMS Immunology and Medical Microbiology·L CelliniN Allocati
Mar 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T BordiaM Ali
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Sep 23, 2000·Nature·A J Lusis
Feb 13, 2001·The Journal of Clinical Investigation·T Collins, M I Cybulsky
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Feb 7, 2003·Current Cancer Drug Targets·Martha Thomson, Muslim Ali
Jan 22, 2004·International Immunology·Miriam PatyaAbraham Novogrodsky
Jun 17, 2004·Circulation·Rodolfo PaolettiDavid P Hajjar
Jun 17, 2009·Current Opinion in Gastroenterology·David H Alpers

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Citations

Sep 27, 2013·Journal of Medicinal Food·Kuan-Hung LinPi-Yu Chao
Oct 22, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Il Sook ChoiYoung Soon Lee
Oct 27, 2012·Journal of Photochemistry and Photobiology. B, Biology·Seon Hee KimHyung Joo Suh
Jan 19, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tuqa Saleh Al-ShehabiAli H Eid
Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi Yeong JeongDawon Kang
May 12, 2015·Journal of Immunology Research·Rodrigo ArreolaDaniel Ortuño-Sahagún
Sep 15, 2016·Journal of Medicinal Food·Xing Lin HoWai Mun Loke
Oct 11, 2017·MicrobiologyOpen·Zhichang QiuXuguang Qiao
Apr 18, 2014·Nutrition Research and Practice·Cheol ParkYung Hyun Choi
May 20, 2020·The Journal of Physiology·Wenly RuanJames Versalovic
Sep 16, 2017·Journal of Food and Drug Analysis·Shunsuke KimuraKuan-Chen Cheng
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji Hyeon Ryu, Dawon Kang
Oct 1, 2016·Phytotherapy Research : PTR·Dong-Gyu KimJung Hye Shin
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Zhichang QiuXuguang Qiao

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