Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Iva VukelićRobert Domitrović

Abstract

Chlorogenic acid (ChA) exhibits a multitude of positive health effects, however, the signaling mechanisms by which ChA could influence the inflammatory response in experimental colitis are unknown. To answer this question, we induced colitis in mice by administration of 2.5% dextran sulfate sodium (DSS) in drinking water for seven days. Oral administration of ChA significantly ameliorated clinical symptoms, improved disease activity index and colon shortening induced by DSS. Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. Immunohistochemical analysis showed a dose-dependent decrease in expression and nuclear translocation of nuclear factor-kappa B (NF-κB) p65 subunit, which was accompanied by suppression of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) expression. Induction of apoptosis and oxidative stress was attenuated in a dose-dependent manner by suppressing Bax, caspase-8, caspase-9 and heme oxygenase-1 (HO-1) protein expression in m...Continue Reading

Citations

Dec 14, 2018·International Journal of Molecular Sciences·Valéria Costa da SilvaGerlane Coelho Bernardo Guerra
Jan 10, 2019·Journal of Biomedical Science·Jonatas Rafael de OliveiraLuciane Dias de Oliveira
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Iva VukelićRobert Domitrović
Dec 18, 2020·Respiratory Physiology & Neurobiology·Naga K R Ghattamaneni, Lindsay Brown
Jan 19, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Si-Yi LiYong-Qiang Liu
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·William LeonardZhongxiang Fang
Jun 22, 2021·Synthetic and Systems Biotechnology·Jing LiuZhiliang Gao
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani
Nov 18, 2018·International Journal of Biological Macromolecules·Qiuxuan YangXiming Xu

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