Chlorogenic acid ameliorates intestinal mitochondrial injury by increasing antioxidant effects and activity of respiratory complexes

Bioscience, Biotechnology, and Biochemistry
Yan ZhouYulong Yin

Abstract

Dietary polyphenols are thought to be beneficial for human health by acting as antioxidants. Chlorogenic acid (CGA) is abundant in plant-based foods as an ester of caffeic acid and quinic acid. In this study, we investigated the effects of CGA on mitochondrial protection. Our results demonstrated that pretreatment with CGA ameliorated the intestinal mitochondrial injury induced by H2O2; membrane potential was increased, mitochondrial swelling, levels of reactive oxygen species, contents of 8-hydroxy-2-deoxyguanosine, and cytochrome c released were decreased. The beneficial effects of CGA were accompanied by an increase in antioxidant and respiratory-chain complex I, IV, and V activities. In trinitrobenzene-sulfonic acid-induced colitic rats indicated that CGA supplementation improved mitochondria ultrastructure and decreased mitochondrial injury. Our results suggest a promising role for CGA as a mitochondria-targeted antioxidant in combating intestinal oxidative injury. Daily intake of diets containing CGA, such as coffee and honeysuckle, may be useful for prevention of intestinal diseases.

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Citations

Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingyue JiMinhui Li
Sep 4, 2020·Journal of Biochemical and Molecular Toxicology·Jeremiah ArowoogunOluwatosin A Adaramoye

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Methods Mentioned

BETA
light-scattering
light scattering
flow cytometry
enzyme-linked immunosorbent assay
biopsy

Software Mentioned

SPSS

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