Chlorogenic acid ameliorates obesity by preventing energy balance shift in high-fat diet induced obese mice.

Journal of the Science of Food and Agriculture
Xiaoyun HeChanghui Zhao

Abstract

Chlorogenic acid is a type of phenolic acid found in many plants. Chlorogenic acid has an anti-obesity effect with an unclear mechanism. The present study aimed to investigate the regulatory effect of chlorogenic acid on energy balance in high-fat diet (HFD) induced obese C57BL/6J mice administrated 100 mg kg-1 chlorogenic acid for 13 weeks. The consumption of chlorogenic acid ameliorated HFD induced obesity. Chlorogenic acid did not change the physical activity but significantly decreased food intake and increased body temperature, thermal dissipation and brown adipose tissue activity. Moreover, chlorogenic acid improved glucose tolerance but had a moderate impact on other blood indices. Additionally, chlorogenic acid failed to restore the microbiota change associated with HFD induced obesity, but modified the gut bacterial composition in a unique way. Supplementation with chlorogenic acid can improve HFD induced obesity and associated glucose intolerance mainly via regulating food intake and energy expenditure. © 2020 Society of Chemical Industry.

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Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika BhardwajSudhir Kumar Kataria
Jul 20, 2021·Frontiers in Pharmacology·Ameng ShiHaitao Shi
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He

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