Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells.

European Journal of Nutrition
Weng-Cheng ChangYa-Mei Yu

Abstract

Expression of cell adhesion molecules (CAM) on the endothelium and the attachment of monocytes to endothelium may play a major role in the early atherogenic process. Chlorogenic acid is a phenolic compound present in coffee, apples, pears, berries, almonds, artichokes, and aubergines. Previous studies have indicated that CA possesses antioxidant activity in vitro. We investigated the effects of chlorogenic acid and probucol on monocyte-like adhesion, adhesion molecule expression, NF-kappaB translocation and ROS production in IL-1beta-induced human umbilical vein endothelial cells (HUVECs). According to the results of the MTT assay, we chose 25 and 50 mumol/L to perform the experiments. Chlorogenic acid dose-dependently suppressed IL-1beta-induced mRNA expression of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1 and endothelial cell selectin. Chlorogenic acid also suppressed the IL-1beta-induced production of ROS. We also observed that chlorogenic acid attenuated or blocked IL-1beta-induced nuclear translocation of nuclear factor-kappaB subunits p50 and p65, which in turn attenuated CAM expression at the transcription level. Furthermore, chlorogenic acid significantly reduced the adhesion of human mono...Continue Reading

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Citations

Aug 25, 2011·European Journal of Nutrition·D Zapolska-DownarD Sitkiewicz
Jul 26, 2011·The Proceedings of the Nutrition Society·Wendy Russell, Garry Duthie
Nov 14, 2013·Nutrition & Metabolism·Shinichi MeguroTadashi Hase
Nov 26, 2013·Experimental Gerontology·Yinting GuoRyoichi Nagatomi
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Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

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