Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats

Nutrition Research
Nikhil S BhandarkarSunil K Panchal

Abstract

Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes. We hypothesized that chlorogenic acid would improve cardiovascular, liver, and metabolic responses in a rat model of metabolic syndrome induced by a high-carbohydrate, high-fat diet. Male Wistar rats (8-9 weeks old, 335 ± 2 g, n = 48) were divided into 4 groups and fed with corn starch diet (16 weeks); corn starch diet with chlorogenic acid in food for the last 8 weeks; high-carbohydrate, high-fat diet (16 weeks); or high-carbohydrate, high-fat diet with chlorogenic acid (~100 mg/kg/d) in food for the last 8 weeks. In high-carbohydrate, high-fat diet-fed rats, chlorogenic acid reduced energy intake and food efficiency to reduce visceral fat, especially retroperitoneal fat, and abdominal circumference; reversed the elevated systolic blood pressure; and attenuated left ventricular diastolic stiffness with reduced collagen deposition and infiltration of inflammatory cells in the left ventricle. Chlorogenic acid decreased inflammation and fat deposition in the liver along with reduced plasma liver enzyme activities of obese rats but did no...Continue Reading

Citations

Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sana Ben-OthmanRajeev Bhat
Feb 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nikhil S BhandarkarSunil K Panchal
Sep 29, 2020·Frontiers in Plant Science·María Valeria LaraMaría Fabiana Drincovich
Aug 18, 2020·Food Chemistry·Fábio Fernandes de AraújoGlaucia Maria Pastore
Dec 18, 2020·Respiratory Physiology & Neurobiology·Naga K R Ghattamaneni, Lindsay Brown

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