Chlorogenic Acid Improves Intestinal Development via Suppressing Mucosa Inflammation and Cell Apoptosis in Weaned Pigs

ACS Omega
Jiali ChenJun He

Abstract

Chlorogenic acid (CGA) is a naturally occurring polyphenol in the human diet and plants, exhibiting antioxidant and anti-inflammatory activities. This study was conducted to investigate the effects of CGA on intestinal development and health in weaned pigs. Twenty-four weaned pigs were randomly assigned to two treatments and fed with a basal diet or a basal diet supplemented with 1000 mg/kg CGA. After a 14 d trial, samples were collected. Compared with the control group, CGA supplementation decreased the serum tumor necrosis factor-α, interleukin-6, and interleukin-1βIL-6 concentrations and elevated the serum immunoglobulin G and jejunal secretory immunoglobulin A concentrations. Meanwhile, jejunal villus height, duodenal and jejunal villus width, and jejunal and ileal villus height/crypt depth were increased by CGA. CGA not only decreased the number of duodenal and jejunal cells in the G0G1 phase but also increased the number of jejunal and ileal cells in the S phase. The percentages of late and total apoptotic cells in jejunum and the ratio of B-cell lymphoma-2-assiciated X protein to B-cell lymphoma-2 (Bcl-2) in duodenum and jejunum were also decreased by CGA supplementation. Finally, CGA upregulated the expression level of ...Continue Reading

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Citations

Oct 22, 2019·Current Neuropharmacology·Deniz BagdasMine Sibel Gurun
Jun 11, 2020·Animals : an Open Access Journal From MDPI·Udani A WijesiriwardanaFrank R Dunshea
Aug 12, 2019·Applied Microbiology and Biotechnology·Jiali ChenJun He
Oct 1, 2020·Animals : an Open Access Journal From MDPI·Giulia Ferronato, Aldo Prandini
Sep 10, 2018·Biological Trace Element Research·Tongsen ZhangJiandong Tai
Sep 23, 2020·Ecotoxicology and Environmental Safety·Xiaoxiang XuFushan Lu
Oct 16, 2020·Journal of Biochemical and Molecular Toxicology·Zahra ChangiziAkram Eidi

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Methods Mentioned

BETA
flow cytometry
scraping
ELISA
electrophoresis
PCR
scanning electron microscopy

Software Mentioned

Pro Plus
Image
SAS

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