Chlorogenic Acid Improves Neuroprotective Effect of PEP-1-Ribosomal Protein S3 Against Ischemic Insult.

Experimental Neurobiology
Eun Hee AhnSoo Young Choi

Abstract

Chlorogenic acid (CGA) possesses various biological activities such as anti-oxidant, anti-inflammatory, and anti-diabetic activities. In the present study, we examined the effect of CGA on the transduction efficiency of PEP-1-ribosomal protein S3 (PEP-1-rpS3) into cells and brain tissues, and its neuroprotective potential against ischemia/reperfusion. We found that, in the presence of CGA, the transduction efficiency of PEP-1-rpS3 into astrocytes and the CA1 region of the hippocampus was enhanced, compared to its transduction in the absence of CGA. Also, cell viability data demonstrated that the sample treated with CGA + PEP-1-rpS3 exhibited improved cell viability against hydrogen peroxide (H(2)O(2))-induced toxicity more significantly than the sample treated with PEP-1-rpS3 alone. Also, in a gerbil ischemia model, data demonstrated that following the ischemic insult, the group treated with PEP-1-rpS3 + CGA showed markedly enhanced protection of neuron cells in CA1 region of hippocampus, compared to those treated with CGA or PEP-1-rpS3 alone. Taken together, these results suggest that CGA may improve the transduction efficiency of protein transduction domain (PTD) fusion proteins into target cells or tissues, thereby enhancing...Continue Reading

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Citations

Jul 25, 2014·BioMed Research International·Renata FrancikSławomir Francik
May 7, 2013·Expert Opinion on Investigational Drugs·Lokesh PathakAshish Dhir
Jul 22, 2014·International Journal of Dermatology·Yoichi FukushimaKazuo Kondo
Feb 27, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Gaurav KumarRanjana Patnaik
Aug 23, 2019·The European Journal of Neuroscience·Ery HermawatiGinus Partadiredja
Jun 14, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Gaurav KumarRanjana Patnaik
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Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Oct 8, 2021·Environmental Science and Pollution Research International·Rahul TripathiPravir Kumar

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Methods Mentioned

BETA
electrophoresis
biopsy

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