Abstract
Asthma is a chronic inflammatory disease of the airways characterized by reversible airway obstruction, airway hyperreactivity, and remodeling of the airways. Chlorogenic acid (CGA), an ester of caffeic acid with quinic acid, is one of the most abundant polyphenol compounds in various agricultural products. CGA shows various biological properties, such as anti-oxidant, anti-viral, anti-carcinogenic and anti-inflammatory activities. We investigated suppressive effects of CGA on ovalbumin (OVA)-induced allergic asthma in mice and underlying mechanisms of them. CGA significantly reduced pulmonary eosinophilia and expression of IL-4, IL-5 and TNF-α in the lung as well as the serum levels of total and OVA-specific IgE, while CGA enhanced those of total and OVA-specific IgG3, of which isotype switching is down-regulated by IL-4. In vitro IgE production from LPS/IL-4-stimulated splenocytes was remarkably reduced by CGA, while that of IgG3 was enhanced. The Cε germ line transcription, which is necessary for IL-4 mediated IgE isotype switching, was reduced by CGA in LPS/IL-4-stimulated splenocytes. IgE isotype switching is mediated via several transduction pathways, activating several molecules including STAT-6, NF-κB, ERK1/2, and JNK. ...Continue Reading
References
Jan 1, 1992·International Archives of Allergy and Immunology·W ElwoodK F Chung
Apr 1, 1992·The Journal of Experimental Medicine·J M Purkerson, P C Isakson
Dec 1, 1991·The Journal of Allergy and Clinical Immunology·C WalkerK Blaser
May 1, 1988·The Journal of Experimental Medicine·Y YamaguchiK Takatsu
Jan 1, 1988·The Journal of Experimental Medicine·C M SnapperW E Paul
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A J CoyleG P Anderson
Aug 23, 1993·FEBS Letters·G F Sud'inaS D Varfolomeev
Feb 1, 1993·The Journal of Experimental Medicine·I IwamotoS Yoshida
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G G BrusselleH Bluethmann
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·K NatarajanB B Aggarwal
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·I IwamotoA Nakao
Jul 1, 1997·The European Respiratory Journal·S J Szefler, D Y Leung
Mar 21, 1998·Bioscience, Biotechnology, and Biochemistry·Y KonoH Shibata
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·P J Barnes
Feb 11, 1999·Journal of the American Dietetic Association·A King, G Young
Aug 6, 2000·Immunology·S ChenU Mohammed
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·D H BroideP Sriramarao
May 23, 2002·Immunopharmacology and Immunotoxicology·Teresa Krakauer
Sep 2, 2003·Nature Reviews. Immunology·Raif S GehaScott R Brodeur
Nov 11, 2003·Trends in Pharmacological Sciences·Fabio L M Ricciardolo
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Haifa H Jabara, Raif S Geha
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Il-Whan ChoiHern-Ku Lee
Dec 11, 2007·International Immunopharmacology·Jin-Ah LeeJoo-Hung Park
Mar 31, 2009·Biochimie·Yanxia YinQun Wei
Mar 31, 2009·Planta medica·Shwu-Huey WangChun-Mao Lin
May 26, 2009·Antiviral Research·Gui-Feng WangJian-Ping Zuo
Jul 15, 2009·Planta medica·Joanna FolwarcznaHenryk I Trzeciak
Nov 26, 2009·Planta medica·Maria ZychHenryk I Trzeciak
Citations
May 9, 2014·PloS One·Min JiangGuo-an Luo
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ju-Hyun GongYoung-Hee Kang
Jul 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chao-Wen ChengJin-Shuen Chen
May 15, 2012·Brain Research Bulletin·Wenjuan ShenDaxiang Lu
Jul 4, 2015·Molecular Immunology·Hui-Mei WuRong-Yu Liu
Mar 19, 2011·Journal of Ethnopharmacology·C B HebedaS H P Farsky
Jun 12, 2013·Pharmaceutical Biology·Mi Jeong SungJin-Taek Hwang
Mar 7, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Hubert ZatorskiJakub Fichna
Sep 23, 2014·Pulmonary Pharmacology & Therapeutics·Christian GreunkeHanns Häberlein
Apr 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miranda S M TsangChun K Wong
Mar 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyung-Jae ChoiSeung-Sik Cho
Sep 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung-Hui SongSeung-Sik Cho
Feb 7, 2019·Journal of the Science of Food and Agriculture·Mekhala Dk VithanaStuart K Johnson
May 12, 2018·Inflammopharmacology·Janka Schulte-MichelsSebastian Franken
Jun 21, 2020·Clinical and Experimental Immunology·J WieczfinskaR Pawliczak
Jul 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun YinMin Won Lee
Feb 5, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan GaoYun Qi
Feb 12, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Andiamira Cagnoni BalestraMarcos C Borges
Sep 24, 2020·Journal of Food Biochemistry·Yueh-Lun LeeChen-Chen Lee
Oct 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miranda Sin-Man TsangChun-Kwok Wong
Jun 18, 2011·Molecular Biology Reports·Yan-Jun HuYu Ou-Yang
Apr 2, 2016·International Journal of Molecular Medicine·Ji-Hye SeoDae-Hun Park
Nov 14, 2020·Journal of Ethnopharmacology·Jun-Xi LiuJun Liang
Jul 12, 2019·Food Chemistry·Rishipal R BansodeLeonard L Williams
Mar 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chung-Jen ChiangLi-Jen Lin
Apr 5, 2014·Journal of Agricultural and Food Chemistry·Antonieta RuizIsidro Hermosín-Gutiérrez