May 30, 2020

Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety

MedRxiv : the Preprint Server for Health Sciences
M. takla, Kamalan Jeevaratnam

Abstract

Background: The COVID-19 pandemic has required clinicians to urgently identify new treatment options or the repurposing of existing drugs. Several drugs are now being repurposed with the aim of identifying if these drugs provide some level of disease resolution. Of particular interest are chloroquine (CQ) and hydroxychloroquine (HCQ), first developed as an antimalarial therapy. There is increasing concern with regards to the efficacy and safety of these agents. The aims of this review are to systematically identify and collate studies describing the use of CQ and HCQ in human clinical trials and provide a detailed synthesis of evidence of its efficacy and safety. Methods and Findings: Searches for (COVID AND chloroquine [title/abstract] AND outcomes[full text]) and two (COVID AND hydroxychloroquine[title/abstract] AND outcomes[full text]) yielded 272 unique articles. Unique articles were manually checked for inclusion and exclusion criteria and also subjected to a quality appraisal assessment. A total of 19 articles were included in the systematic review. Seventy-five percent of observational studies employing an endpoint specific to efficacy recorded no significant difference in the attainment of outcomes, between COVID-19 pat...Continue Reading

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Mentioned in this Paper

Clinical Trials
Evaluation
Hospital Administration
Diagnosis
Clinician
Adverse Effects
Elevation
Hydroxychloroquine
Tachycardia, Ventricular
Mental Depression

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