PMID: 8471829Mar 1, 1993Paper

Chloroquine-induced seizures in mice: the role of monoaminergic mechanisms

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
G J Amabeoku, O Chikuni

Abstract

The influence of some dopaminergic and noradrenergic agents on seizures induced by chloroquine (45-100 mg/kg, i.p.) was investigated in mice. Apomorphine (0.2-0.8 mg/kg, s.c.). L-dopa (25-50 mg/kg, s.c.) benserazide (5 mg/kg, i.p.) plus L-dopa (50 mg/kg, s.c.), pargyline (100 mg/kg, i.p.), FLA-63 (10-20 mg/kg, s.c.) and FLA-63 (10 mg/kg, s.c.) plus L-dopa (50 mg/kg, s.c.) profoundly shortened the latency of seizures induced by chloroquine (65 mg/kg, i.p.). L-Dopa (50 mg/kg, s.c.) weakly reduced the latency and weakly increased the incidence of chloroquine (50 mg/kg, i.p.)-induced seizures. alpha-Methyl-p-tyrosine (25-100 mg/kg, i.p.) dose-dependently and significantly reduced the incidence and significantly prolonged the latency of chloroquine (65 mg/kg, i.p.)-induced seizures. However, L-dopa (50 mg/kg, s.c.) effectively increased the proportion of animals convulsing and effectively reduced the latency of seizures induced by chloroquine (65 mg/kg, i.p.) in alpha-methyl-p-tyrosine-pretreated mice. Haloperidol (0.25-1.0 mg/kg, i.p.) and pimozide (2-4 mg/kg, i.p.) markedly reduced the incidence and markedly prolonged the latency of seizures induced by chloroquine (65 mg/kg, i.p.) in a dose-related manner. However, apomorphine (0....Continue Reading

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Citations

Apr 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G AmabeokuE Bwakura
Feb 13, 2001·Tropical Medicine & International Health : TM & IH·J CrawleyK Marsh
Feb 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A CapassoL Sorrentino

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