Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria: II. Correlation of in vitro with in vivo sensitivity

Transactions of the Royal Society of Tropical Medicine and Hygiene
A F AderounmuO Walker

Abstract

Plasmodium falciparum malaria was treated in 82 children with 25 mg/kg chloroquine orally over three days. They were observed for 28 days during which blood films were examined periodically for malaria parasites. Asexual forms of P. falciparum, present in the blood films of all the patients before commencing treatment, disappeared rapidly and by the third day no parasites were seen in blood films from any of them. Among the patients observed for more than three days, blood films remained negative throughout the observation period. In vitro tests of sensitivity of blood samples from 10 patients showed chloroquine concentrations of 0.5 to 0.8 nmol/ml to inhibit completely maturation from ring forms to schizonts. This suggests that P. falciparum in the Ibadan area is probably still fully sensitive to chloroquine.

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Olatunde
Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·S FoghP Effersøe
Nov 1, 1979·The American Journal of Tropical Medicine and Hygiene·R A Eke
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Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·A F AderounmuS A Adelusi

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Citations

Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·A OlatundeO Walker
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·O WalkerO Sodeinde
Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M S MadhyasthaR R Marquardt
Sep 11, 1982·British Medical Journal·L J Bruce-Chwatt
Oct 1, 1990·Annals of Tropical Medicine and Parasitology·L A SalakoO Walker
Aug 1, 1989·Annals of Tropical Medicine and Parasitology·H I Daniel, N B Molta

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