Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas.

Chemical Communications : Chem Comm
Meiqing LiLijing Fang

Abstract

A convenient and efficient strategy was developed for accessing chlorotoxin-derived bicyclic peptide-biomolecule conjugates by cyclizing fully-unprotected linear peptides with a designed tetrafunctional chemical linker. Among these peptides, bicycle-P3 bearing the N-terminal sequence of chlorotoxin shows high tumor selectivity and penetration ability, which is promising for treatment of gliomas.

References

Feb 1, 1993·The American Journal of Physiology·J A DeBinG R Strichartz
Nov 28, 2002·The Journal of Biological Chemistry·Jessy DeshaneHarald Sontheimer
Apr 7, 2005·Chembiochem : a European Journal of Chemical Biology·Peter TimmermanRob H Meloen
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam N MamelakMatthew A Gonda
Jun 2, 2009·Nature Chemical Biology·Christian HeinisGreg Winter
Nov 28, 2012·Nature Reviews. Clinical Oncology·Shota TanakaJorg Dietrich
Apr 1, 2012·Drug Discovery Today. Technologies
Oct 19, 2013·Experimental and Therapeutic Medicine·Xiao-Min WangZhan-Yun Guo
Jan 23, 2014·Chemical Reviews·Miriam Góngora-BenítezFernando Albericio
Jan 24, 2014·Angewandte Chemie·Shiyu ChenChristian Heinis
Nov 19, 2014·Future Medicinal Chemistry·Paola G OjedaDavid J Craik
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
Sep 30, 2015·Biopolymers·Paola G OjedaDavid J Craik
Feb 6, 2016·Toxins·Syed Abid AliWolfgang Voelter
Jun 8, 2017·Chemistry : a European Journal·Curran A Rhodes, Dehua Pei
Jul 19, 2017·Accounts of Chemical Research·Kaycie DeyleChristian Heinis
Jul 24, 2018·Cancer Treatment Reviews·Florence LefrancMichael Weller
Nov 30, 2018·Toxins·Gadi CohenJoseph A Frank
Apr 6, 2019·Frontiers in Pharmacology·Mohadeseh DastpeymanNorelle L Daly

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
acylation
acetylation
circular dichroism
confocal
fluorescence activated cell sorting
FACS
Flow cytometry
xenograft
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Discovery Today
Shahrzad AhangarzadehLobat Tayebi
Chemistry : a European Journal
Curran A Rhodes, Dehua Pei
© 2021 Meta ULC. All rights reserved